Citation: Tianyu Chen, Dexuan Xiao, Yanjing Li, Sirong Shi, Xiao Yang, Shuanglin Peng, Bin Guo, Xiaoxiao Cai. Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells[J]. Chinese Chemical Letters, ;2022, 33(5): 2517-2521. doi: 10.1016/j.cclet.2021.11.090 shu

Tetrahedral framework nucleic acids regulate osteogenic differentiation potential of osteoporotic adipose-derived stem cells

Tianyu Chen ^a ,
Dexuan Xiao ^a ,
Yanjing Li ^a ,
Sirong Shi ^a ,
Xiao Yang ^a ,
Shuanglin Peng ^a ,
Bin Guo ^{b, *,} ,
Xiaoxiao Cai ^{a, *,}

a.
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
Department of Stomatology, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

guobin0408@126.com

xcai@scu.edu.cn

Received Date: 29 September 2021
Revised Date: 26 November 2021
Accepted Date: 30 November 2021
Available Online: 4 December 2021
Fund Project: the National Key R & D Program of China 2019YFA0110600National Natural Science Foundation of China 82171006National Natural Science Foundation of China 81970986National Natural Science Foundation of China 81771125National Natural Science Foundation of China 82001432West China Hospital Postdoctoral Science Foundation 2020HXBH104

Figures(4)

Osteoporosis (OP) is a noncommunicable bone disease caused by a shift in the balance between osteoblasts and osteoclasts, and can severely affect the health of elderly persons. Autologous stem-cell transplantation can improve reduced bone density and weakened fracture healing abilities in patients with OP. However, OP can adversely affect the osteogenesis and proliferation abilities of autologous adipose-derived stem cells (ASCs). Therefore, an effective drug is required to facilitate autologous ASCs to recover their osteogenic and proliferative potential. Tetrahedral framework nucleic acid (tFNA) is a new type of nanomaterial that has ability to regulate the biological behavior of cells effectively and enhance the bioactivity of stem cells. In this study, we examine the effects of tFNAs on the osteogenic differentiation and proliferation abilities of ASCs in rats with OP. The results indicate that the 250 nmol/L tFNAs can considerably increase the expression of osteogenesis-related markers, effectively promote the proliferation and osteogenic differentiation of osteoporotic ASCs (OP-ASCs), and help them to regain their osteogenic and proliferative potential. In short, tFNAs can enable OP-ACSs to recover their osteogenic potential and promote their proliferation and, therefore, can play a key regulatory role in autologous ASC transplantation.
- Osteoporosis,
- Tetrahedral framework nucleic acid,
- Adipose-derived stem cell,
- Autologous stem-cell transplantation,
- Osteogenic differentiation
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