Citation: Yunchu Zhang, Tingting Li, Yuzhu Hu, Jing Chen, Yihong He, Xiang Gao, Yan Zhang. Co-delivery of doxorubicin and curcumin via cRGD-peptide modified PEG-PLA self-assembly nanomicelles for lung cancer therapy[J]. Chinese Chemical Letters, ;2022, 33(5): 2507-2511. doi: 10.1016/j.cclet.2021.11.076 shu

Co-delivery of doxorubicin and curcumin via cRGD-peptide modified PEG-PLA self-assembly nanomicelles for lung cancer therapy

Yunchu Zhang ^{a, b, 1} ,
Tingting Li ^{a, b, 1} ,
Yuzhu Hu ^{a, b, 1} ,
Jing Chen ^b ,
Yihong He ^b ,
Xiang Gao ^{b, *,} ,
Yan Zhang ^{a, *,}

a.
Department of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
b.
Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China

xianggao@scu.edu.cn

zhang.yan@scu.edu.cn

Received Date: 22 September 2021
Revised Date: 17 November 2021
Accepted Date: 26 November 2021
Available Online: 2 December 2021

Figures(5)

Lung cancer is the most common malignancy in the world, with a high mortality rate. Nevertheless, therapies to act effectively against lung cancer remain elusive. So far, chemotherapy is still the frontline treatment of lung cancer. Doxorubicin (DOX) is a broad-spectrum anti-tumor drug. However, DOX often has serious side effects and causes multi-drug resistance, which greatly limits its clinical application. In this work, biodegradable methoxy poly(ethylene glycol)-poly(lactic acid) (MPEG-PLA) and cyclo(Arg-Gly-Asp-d-Phe-Lys) (cRGD) polypeptide modified PEG-PLA (cRGD-PEG-PLA) copolymers were used for the co-delivery of curcumin (CUR) and DOX (CUR-DOX/cRGD-M). The particle size of the self-assembled drug-loaded nanomicelle approximately was 27.4 nm and the zeta potential was −2.7 mV. Interestingly, CUR can enhance the uptake of DOX by Lewis lung carcinoma (LL/2) cells. The experimental results in vivo and in vitro showed that CUR-DOX/cRGD-M combination therapy could promote apoptosis of lung cancer cells, and conspicuously inhibit the tumor growth. Our data indicate that CUR-DOX/cRGD-M will be biodegradable and sustainable, which may have potential clinical application value in the treatment of lung cancer.
- Doxorubicin,
- Curcumin,
- Lung cancer,
- Nanomicelle,
- Co-delivery
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