Citation: Xiang Chen, Zhihong Zhu, Shanshan Liu, Yi-Hung Chen, Xiao Shen. MnBr₂ catalyzed regiospecific oxidative Mizoroki-Heck type reaction[J]. Chinese Chemical Letters, ;2022, 33(5): 2391-2396. doi: 10.1016/j.cclet.2021.10.083 shu

MnBr₂ catalyzed regiospecific oxidative Mizoroki-Heck type reaction

Institute for Advanced Studies, Engineering Research Center of Organosilicon Compounds & Materials, Ministry of Education, Wuhan University, Wuhan 430072, China

xiaoshen@whu.edu.cn

Received Date: 26 August 2021
Revised Date: 22 October 2021
Accepted Date: 27 October 2021
Available Online: 2 November 2021

Figures(5)

Herein, we report an unprecedented regiospecific oxidative Mizoroki-Heck type reaction for the synthesis of α-difluoromethyl homoallylic alcohols. The reaction shows broad substrate scopes and high functional group tolerance. Late-stage functionalization of complex biologically active molecules demonstrates the synthetic potential of this transformation. Mechanistic study supports the involvement of MnBr₂ catalyzed radical 1, 2-silyl transfer.
- Fluoroalkylation,
- Mizoroki-Heck,
- Mn catalysis,
- Radical 1, 2-silyl transfer,
- Homoallylic alcohols
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MnBr2 catalyzed regiospecific oxidative Mizoroki-Heck type reaction

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MnBr₂ catalyzed regiospecific oxidative Mizoroki-Heck type reaction