Citation: Yaqiu Zhao, Shunli Xiao, Yun You, Zhi Zhang, Liansuo Zu, Luqi Huang. Total synthesis and biological evaluation of dracaenins A and B[J]. Chinese Chemical Letters, ;2022, 33(5): 2433-2436. doi: 10.1016/j.cclet.2021.10.067 shu

Total synthesis and biological evaluation of dracaenins A and B

Yaqiu Zhao ^{a, c} ,
Shunli Xiao ^c ,
Yun You ^c ,
Zhi Zhang ^{b, *,} ,
Liansuo Zu ^{b, *,} ,
Luqi Huang ^{c, *,}

a.
College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
b.
School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China
c.
State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China

zhangz2019@mail.tsinghua.edu.cn

zuliansuo@tsinghua.edu.cn

huangluqi01@126.com

Received Date: 3 September 2021
Revised Date: 21 October 2021
Accepted Date: 22 October 2021
Available Online: 29 October 2021

Figures(4)

The first total synthesis of dracaenins A and B is achieved in four steps. The synthesis features the convergent coupling of three readily available fragments with minimized use of protecting groups. The chemical synthesis enables the discovery of their activity in stimulating platelet aggregation, and thus, sheds light on the possible origin of the hemostatic effect of dragon's blood.
- Total synthesis,
- Natural product,
- Dragon's blood,
- Dracaenin,
- Hemostasis
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