Citation: Hang Liu, Zhaohua Miao, Zhengbao Zha. Cell membrane-coated nanoparticles for immunotherapy[J]. Chinese Chemical Letters, ;2022, 33(4): 1673-1680. doi: 10.1016/j.cclet.2021.10.057 shu

Cell membrane-coated nanoparticles for immunotherapy

School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China

zbzha@hfut.edu.cn

Received Date: 25 June 2021
Revised Date: 18 October 2021
Accepted Date: 19 October 2021
Available Online: 26 October 2021

Figures(8)

Nanoparticle-based disease detection, prevention and therapies have gained increased interests in biomedical applications, owing to their significant advantages in therapeutic efficacy and safety. Nonetheless, suffering from the challenges including fast recognition and clearance of foreign nanoparticles by innate immune system before arriving at diseased regions, clinical applications of nanoparticles are usually intercepted. Among various strategies for reducing non-specific phagocytosis and enhancing disease-targeting efficiency of nanoparticles, membrane coating nanotechnology exhibits great potential in the disease diagnosis and therapeutics due to both the structural and functional preservation of membrane proteins from source cells. Benefiting the inherited immune-regulation capacities, this review mainly summarized the latest development of such biomimetic nanoparticles for immunotherapy in treating immune-related diseases including microbial infections, inflammation, tumor and autoimmune diseases.
- Biomimetic nanoparticles,
- Immunotherapy,
- Nanovaccine,
- Cell membrane
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