Citation: Zhuo Yu, Wenbo Huang, Liqiao Shi, Shaoyong Ke, Shengzhen Xu. Selective probes targeting c-MYC Pu22 G-quadruplex and their application in live mice imaging[J]. Chinese Chemical Letters, ;2022, 33(3): 1627-1631. doi: 10.1016/j.cclet.2021.09.087 shu

Selective probes targeting c-MYC Pu22 G-quadruplex and their application in live mice imaging

Zhuo Yu ^{a, b} ,
Wenbo Huang ^a ,
Liqiao Shi ^a ,
Shaoyong Ke ^{a, *,} ,
Shengzhen Xu ^{b, *,}

a.
National Biopesticide Engineering Research Centre, Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan 430064, China
b.
College of Science, Huazhong Agricultural University, Wuhan 430070, China

shaoyong.ke@nberc.com

xusz@mail.hzau.edu.cn

Received Date: 30 June 2021
Revised Date: 15 September 2021
Accepted Date: 24 September 2021
Available Online: 30 September 2021

Figures(5)

Several probes containing benzothiazole-guided conjugated systems (BGCS) were designed and synthesized, and two molecules (BGCS5 and BGCS6) of which were discovered as selective probes targeting c-MYC Pu22 G-quadruplex DNA. The fluorescence intensity of BGCS5 and BGCS6 in the presence of c-MYC Pu22 far exceeds that of the typical G4 probe TO1. Especially, the fluorescence of BGCS6 increased almost 193-fold in the presence of c-MYC Pu22 G4 compared to that alone in aqueous buffer condition with almost no fluorescence and 10–30 folds than those in the presence of other DNAs, which will be useful tools for disease detection in mammals.
- Benthiazole,
- Conjugated system,
- Chemosensor,
- G-quadruplex DNA,
- In vivo imaging
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