Citation: Hai-Wei Yan, Rong-Rong Du, Xu Zhang, Ya-Nan Yang, Xiang Yuan, Zi-Ming Feng, Jian-Shuang Jiang, Pei-Cheng Zhang. Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma[J]. Chinese Chemical Letters, ;2022, 33(5): 2555-2558. doi: 10.1016/j.cclet.2021.09.064 shu

Arnequinol A and arnequinone A, two unique meroterpenoids from Arnebia euchroma

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

pczhang@imm.ac.cn

Received Date: 22 July 2021
Revised Date: 30 August 2021
Accepted Date: 18 September 2021
Available Online: 24 September 2021

Figures(6)

Arnequinol A (1), featuring an unprecedented 6/6/3 tricyclic carbon skeleton fused with a heptatomic oxo-bridge, together with arnequinone A (2) bearing a highly conjugated methyl-shifting benzogeijerene skeleton, were isolated from Arnebia euchroma. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of the ¹³C nuclear magnetic resonance (NMR) data and electronic circular dichroism (ECD) spectra. The plausible biosynthetic pathways for 1 and 2 were presented. In in vitro test, compound 2 showed potent neuroprotective activity against serum-deprivation induced PC12 cell damage at a concentration of 10 µmol/L.
- Arnebia euchroma,
- Meroterpenoids,
- Arnequinol A and arnequinone A,
- Cytotoxicity,
- Neuroprotective activity
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