Citation: Meng Du, Ming Li, Wangze Song, Nan Zheng. Metal-free multicomponent polymerization toward cationic polyamidines[J]. Chinese Chemical Letters, ;2022, 33(5): 2643-2647. doi: 10.1016/j.cclet.2021.09.031 shu

Metal-free multicomponent polymerization toward cationic polyamidines

Meng Du ¹ ,
Ming Li ¹ ,
Wangze Song ^*, ,
Nan Zheng ^*,

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China

wzsong@dlut.edu.cn

nzheng@dlut.edu.cn

Received Date: 6 August 2021
Accepted Date: 7 September 2021
Available Online: 11 September 2021

Figures(6)

Cationic polymers, also known as polycations, are considered to be the most potential non-viral gene carriers due to their unique advantages such as the ability to bind the negative charge of nucleic acid molecules. Multicomponent polymerization (MCP) is a one-step, tandem strategy to construct complex structures based on multicomponent reactions. Herein, we developed a metal-free MCP method based on three monomers of p-dinitrovinylbenzene (p-DNVB), 1, 1-dimethylethyl N, N-dibromocarbamate (BocNBr₂), and bis-secondary-amines with a ratio of 1:2:1, to access a library of Boc-substituted polyamidines with well-defined structures and suitable molecular weights (M_w ranging from 4400 Da to 11, 000 Da) in high yields (up to 85%) under mild conditions. Upon the removal of Boc groups, a series of water-soluble polymers with cationic property were prepared and their gene binding capability was further evaluated.
- Multicomponent polymerization,
- Metal-free,
- Cationic polymer,
- Polyamidine,
- Water-soluble
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