Citation: Xindi Sun, Qirui Wu, Wei Li, Xiuqing Gong, Jun-Yi Ge, Jinbo Wu, Xinghua Gao. Facile fabrication of drug-loaded PEGDA microcapsules for drug evaluation using droplet-based microchip[J]. Chinese Chemical Letters, ;2022, 33(5): 2697-2700. doi: 10.1016/j.cclet.2021.08.122 shu

Facile fabrication of drug-loaded PEGDA microcapsules for drug evaluation using droplet-based microchip

Materials Genome Institute, Shanghai University, Shanghai 200444, China

jinbowu@t.shu.edu.cn

gaoxinghua@t.shu.edu.cn

Received Date: 25 June 2021
Revised Date: 16 August 2021
Accepted Date: 29 August 2021
Available Online: 4 September 2021

Figures(5)

Droplet-based microfluidic technology can be utilized as a microreactor to prepare novel functional monodisperse microcapsules. In this study, a droplet-based microfluidic chip with surface modification, which allowed the one-step preparation of double emulsion microcapsules. An O/W/O double emulsion using polyethylene (glycol) diacrylate (PEGDA) solution as the intermediate water phase was prepared by regulating the hydrophilicity and hydrophobicity of the chip surface, with PEGDA microcapsules prepared using UV polymerization. And then anti-tumor drug paclitaxel and neurotoxin 6-OHDA were encapsulated in microcapsules for drug and toxicology evaluation, respectively. Compared to controls, drug-loaded microcapsules caused a significant increase in the death rate of PC12 cells. This indicates that the obtained drug-loaded microcapsules could be used in drug evaluation and potentially in drug screening and delivery.
- PEGDA microcapsule,
- Droplet-based microfluidic,
- PC12 cells,
- Drug evaluation
1. [1]
  Y.N. Li, D. Yan, F.F. Fu, et al., Sci. China Mater. 60 (2017) 543-553. doi: 10.1007/s40843-016-5151-6
2. [2]
  P. Agarwal, H. Wang, M.R. Sun, et al., ACS Nano11 (2017) 6691-6702. doi: 10.1021/acsnano.7b00824
3. [3]
  X. Zhao, S. Liu, L. Yildirimer, et al., Adv. Funct. Mater. 26 (2016) 2976-2976.
4. [4]
  T.Y. Lee, S. Lee, Y.H. Kim, et al., Adv. Funct. Mater. 29 (2019) 02670.
5. [5]
  P. Gravesen, J. Branebjerg, O.S. Jensen, J. Micromech. Microeng. 3 (1993) 168-182. doi: 10.1088/0960-1317/3/4/002
6. [6]
  Y.J. Zheng, Z.N. Wu, J.M. Lin, et al., Chin. Chem. Lett. 31 (2020) 165-168.
7. [7]
  M.G.A. Mohamed, P. Ambhorkar, R. Samanipour, et al., Biomicrofluidics14 (2020) 021501. doi: 10.1063/1.5134060
8. [8]
  W. Li, L.Y. Zhang, X.H. Ge, et al., Chem. Soc. Rev. 47 (2018) 5646-5683. doi: 10.1039/C7CS00263G
9. [9]
  C Liu, W Zheng, R Xie, et al., Chin. Chem. Lett. 30 (2019) 457-460. doi: 10.1016/j.cclet.2018.09.010
10. [10]
  S. Barthwal, S. Barthwal, B. Singh, et al., Colloids Surf. A. 597 (2020) 124776. doi: 10.1016/j.colsurfa.2020.124776
11. [11]
  D. Bodas, C.K. Malek, Microelectron. Eng. 83 (2006) 1277-1279. doi: 10.1016/j.mee.2006.01.195
12. [12]
  D. J. McClements, Ann. Rev. Food Sci. Technol. 1 (2010) 241-269. doi: 10.1146/annurev.food.080708.100722
13. [13]
  J.R. Choi, K.W. Yong, J.Y. Choi, et al., Biotechniques66 (2019) 40-53. doi: 10.2144/btn-2018-0083
14. [14]
  Y. Hara, H. Sakagami, H. Shi, et al., IN VIVO. 32 (2018)745-752. doi: 10.21873/invivo.11303
15. [15]
  Z. Tayarani-Najaran, E. Hadipour, S.M.S. Mousavi, et al., Ethnopharmacol. 273 (2021) 114023. doi: 10.1016/j.jep.2021.114023
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2. [2]
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18. [18]
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19. [19]
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20. [20]
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