Citation: Xinming Li, Donglei Shi, Yihe Song, Yixiang Xu, Ying Gao, Wenjing Qiu, Xin Chen, Xiaokang Li, Yunyuan Huang, Yanjun Feng, Baoli Li, Yuan Guo, Jian Li. Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift[J]. Chinese Chemical Letters, ;2022, 33(3): 1572-1576. doi: 10.1016/j.cclet.2021.08.114 shu

Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift

Xinming Li ^a ,
Donglei Shi ^a ,
Yihe Song ^a ,
Yixiang Xu ^a ,
Ying Gao ^b ,
Wenjing Qiu ^a ,
Xin Chen ^a ,
Xiaokang Li ^a ,
Yunyuan Huang ^a ,
Yanjun Feng ^a ,
Baoli Li ^{a, *,} ,
Yuan Guo ^{b, *,} ,
Jian Li ^{a, c, d, e, *,}

a.
State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
b.
Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, China
c.
Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai 200237, China
d.
College of Pharmacy and Chemistry, Dali University, Dali 671000, China
e.
Clinical Medicine Scientific and Technical Innovation Center, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200092, China

libaolilibaoli@163.com

guoyuan@nwu.edu.cn

jianli@ecust.edu.cn

Received Date: 2 June 2021
Revised Date: 18 August 2021
Accepted Date: 24 August 2021
Available Online: 30 August 2021

Figures(5)

Monoamine oxidase A (MAO-A) is a prominent myocardial source of reactive oxygen species (ROS), and its expression and activity are strongly increased in failing hearts. Therefore, accurate evaluation of MAO-A activity in cardiomyocytes is of great importance for understanding its biological functions and early diagnosing the progression of heart failure. However, so far, there is no report on the fluorescent diagnosis of heart failure by a specific probe for MAO-A. In this work, two far-red emissive fluorescent turn-on probes (KXS-M1 and KXS-M2) for the highly selective and sensitive detection of MAO-A were fabricated. Both probes exhibit good response to MAO-A, one of which, KXS-M2, performs better than the other one in terms of a fluorescence increment and sensitivity. Using the pioneering probe KXS-M2, specific fluorescence imaging of MAO-A in glucose-deprived H9c2 cardiac cells, zebrafish and isoprenaline-induced failing heart tissues was achieved, proving that KXS-M2 can serve as a powerful tool for the diagnosis and treatment of heart failure.
- Heart failure,
- Monoamine oxidase A,
- Oxidative stress,
- Fluorescent probe,
- Far-red emission,
- Diagnosis
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