Citation: Jing Guo, Ruichen Shen, Xuejie Shen, Bo Zeng, Nianjun Yang, Huageng Liang, Yanbing Yang, Quan Yuan. Construction of high stability indium gallium zinc oxide transistor biosensors for reliable detection of bladder cancer-associated microRNA[J]. Chinese Chemical Letters, ;2022, 33(2): 979-982. doi: 10.1016/j.cclet.2021.07.048 shu

Construction of high stability indium gallium zinc oxide transistor biosensors for reliable detection of bladder cancer-associated microRNA

Jing Guo ^a ,
Ruichen Shen ^c ,
Xuejie Shen ^c ,
Bo Zeng ^a ,
Nianjun Yang ^d ,
Huageng Liang ^{b, *,} ,
Yanbing Yang ^{a, *,} ,
Quan Yuan ^{a, c, *,}

a.
Key Laboratory of Biomedical Polymers of Ministry of Education, College of Chemistry and Molecular Sciences, School of Microelectronics, Wuhan University, Wuhan 430072, China
b.
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
c.
Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
d.
Institute of Materials Engineering, University of Siegen, Siegen 57076, Germany

leonard19800318@hust.edu.cn

yangyanbing@whu.edu.cn

yuanquan@whu.edu.cn

Received Date: 29 April 2021
Revised Date: 6 July 2021
Accepted Date: 19 July 2021
Available Online: 26 July 2021

Figures(4)

Bladder cancer is the most common malignant tumours with high morbidity, mortality and recurrence. However, currently developed detection methods for bladder cancer-associated urine biomarkers are hindered by their extremely low abundance. Hence, the exploration of a highly sensitive and selective approach for the detection of trace bladder cancer-associated biomarkers in human urine is of vital importance for the diagnosis of bladder cancer. Herein, we developed a highly reliable indium gallium zinc oxide field effect transistor (IGZO FET) biosensor for the detection of bladder cancer-related biomarker microRNA. The single-stranded DNA-functionalized IGZO FET biosensors exhibit high sensing reproducibility and stability with an ultralow detection limit of 19.8 amol/L. The device could also be used for quantitative detection of trace microRNA in human urine samples and can effectively distinguish bladder cancer patients from healthy donors. The development of high performance IGZO FET biosensors presents new opportunities for the achievement of early-stage diagnosis of bladder cancer.
- Bladder cancer,
- Field-effect transistors,
- IGZO,
- miRNA,
- Urine
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