Citation: Ping Huang, Daizheng Lian, Hualin Ma, Nansha Gao, Limin Zhao, Ping Luan, Xiaowei Zeng. New advances in gated materials of mesoporous silica for drug controlled release[J]. Chinese Chemical Letters, ;2021, 32(12): 3696-3704. doi: 10.1016/j.cclet.2021.06.034 shu

New advances in gated materials of mesoporous silica for drug controlled release

Ping Huang ^a ,
Daizheng Lian ^b ,
Hualin Ma ^{b, *,} ,
Nansha Gao ^a ,
Limin Zhao ^{c, *,} ,
Ping Luan ^d ,
Xiaowei Zeng ^{a, *,}

a.
Institute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
b.
Shenzhen Key Laboratory of Kidney Diseases, Department of Nephrology; Department of Radiation Oncology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China
c.
School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510000, China
d.
Health Science Center, Shenzhen University, Shenzhen 518060, China

mahualin0796@sina.com

zhaolimin@gdpu.edu.cn

zengxw23@mail.sysu.edu.cn

Received Date: 29 March 2021
Revised Date: 9 June 2021
Accepted Date: 14 June 2021
Available Online: 20 June 2021

Figures(6)

Drug delivery systems (DDS) are used to deliver therapeutic drugs to improve selectivity and reduce side effects. With the development of nanotechnology, many nanocarriers have been developed and applied to drug delivery, including mesoporous silica. Mesoporous silica nanoparticles (MSNs) have attracted a lot of attention for simple synthesis, biocompatibility, high surface area and pore volume. Based on the pore system and surface modification, gated mesoporous silica nanoparticles can be designed to realize on-command drug release, which provides a new approach for selective delivery of antitumor drugs. Herein, this review mainly focuses on the "gate keepers" of mesoporous silica for drug controlled release in nearly few years (2017–2020). We summarize the mechanism of drug controlled release in gated MSNs and different gated materials: inorganic gated materials, organic gated materials, self-gated drug molecules, and biological membranes. The facing challenges and future prospects of gated MSNs are discussed rationally in the end.
- Mesoporous silica,
- Gated materials,
- Surface modification,
- Drug delivery,
- Controlled release
1. [1]
  C. Li, J. Wang, Y. Wang, et al., Acta Pharm. Sin. B9 (2019) 1145-1162 doi: 10.1016/j.apsb.2019.08.003
2. [2]
  J. Shi, P.W. Kantoff, R. Wooster, O.C. Farokhzad, Nat. Rev. Cancer17 (2017) 20-37 doi: 10.1038/nrc.2016.108
3. [3]
  A. Pugazhendhi, T. Edison, I. Karuppusamy, B. Kathirvel, Int. J. Pharm. 539 (2018) 104-111 doi: 10.1016/j.ijpharm.2018.01.034
4. [4]
  X. Li, A.S. Widjaya, J. Liu, et al., Acta Biomater. 106 (2020) 301-313 doi: 10.1016/j.actbio.2020.02.013
5. [5]
  X. Wei, L. Liu, X. Li, et al., J. Control. Release313 (2019) 42-53 doi: 10.1016/j.jconrel.2019.09.021
6. [6]
  S. Wang, G. Yu, Z. Wang, et al., Angew. Chem. Int. Ed. 58 (2019) 14758-14763 doi: 10.1002/anie.201908997
7. [7]
  K.O. Boakye-Yiadom, S. Kesse, Y. Opoku-Damoah, et al., Int. J. Pharm. 564 (2019) 308-317 doi: 10.1016/j.ijpharm.2019.04.055
8. [8]
  X. Zeng, M. Luo, G. Liu, et al., Adv. Sci. (Weinh. )5 (2018) 1800510 doi: 10.1002/advs.201800510
9. [9]
  F. Zhang, G. Lu, X. Wen, et al., J. Control. Release326 (2020) 131-139 doi: 10.1016/j.jconrel.2020.06.015
10. [10]
  R.R. Castillo, D. Lozano, B. Gonzalez, et al., Expert. Opin. Drug Deliv. 16 (2019) 415-439 doi: 10.1080/17425247.2019.1598375
11. [11]
  M.H. Chan, H.M. Lin, Biomaterials46 (2015) 149-158 doi: 10.1016/j.biomaterials.2014.12.034
12. [12]
  M. Vallet-Regi, M. Colilla, I. Izquierdo-Barba, M. Manzano, Molecules23 (2018) 47
13. [13]
  J. Yang, D. Dai, X. Lou, et al., Theranostics10 (2020) 615-629 doi: 10.7150/thno.40066
14. [14]
  J. Lu, M. Liong, Z. Li, et al., Small6 (2010) 1794-1805 doi: 10.1002/smll.201000538
15. [15]
  M. Vallet-Regi, F. Balas, D. Arcos, Angew. Chem. Int. Ed. 46 (2007) 7548-7558 doi: 10.1002/anie.200604488
16. [16]
  R. Zhao, T. Li, G. Zheng, et al., Biomaterials143 (2017) 1-16 doi: 10.1016/j.biomaterials.2017.07.030
17. [17]
  X. Hong, X. Zhong, G. Du, et al., Sci. Adv. 6 (2020) eaaz4462 doi: 10.1126/sciadv.aaz4462
18. [18]
  C. Chen, W. Yao, W. Sun, et al., Int. J. Biol. Macromol. 122 (2019) 1090-1099 doi: 10.1016/j.ijbiomac.2018.09.058
19. [19]
  X. Ding, W. Yu, Y. Wan, et al., Carbohydr. Polym. 245 (2020) 116493 doi: 10.1016/j.carbpol.2020.116493
20. [20]
  H. Li, X. Wu, B. Yang, et al., Mater. Sci. Eng. C Mater. Biol. Appl. 94 (2019) 453-464 doi: 10.1016/j.msec.2018.09.053
21. [21]
  S.P. Hadipour Moghaddam, R. Mohammadpour, H. Ghandehari, J. Control. Release311-312 (2019) 1-15 doi: 10.1016/j.jconrel.2019.08.028
22. [22]
  G. Yang, S.Z.F. Phua, A.K. Bindra, Y. Zhao, Adv. Mater. 31 (2019) e1805730 doi: 10.1002/adma.201805730
23. [23]
  M. Gautam, R.K. Thapa, B.K. Poudel, et al., Acta Biomater. 88 (2019) 448-461 doi: 10.1016/j.actbio.2019.02.029
24. [24]
  A. Noureddine, A. Maestas-Olguin, E.A. Saada, et al., Acta Biomater. 114 (2020) 358-368 doi: 10.1016/j.actbio.2020.07.027
25. [25]
  C. Argyo, V. Weiss, C. Bräuchle, T. Bein, Chem. Mater. 26 (2013) 435-451
26. [26]
  A. Baeza, M. Vallet-Regi, Pharmaceutics12 (2020) 957 doi: 10.3390/pharmaceutics12100957
27. [27]
  P. Mi, Theranostics10 (2020) 4557-4588 doi: 10.7150/thno.38069
28. [28]
  G. Helmlinger, F. Yuan, M. Dellian, R.K. Jain, Nat. Med. 3 (1997) 177-182 doi: 10.1038/nm0297-177
29. [29]
  J. Jiang, N. Shen, T. Ci, et al., Adv. Mater. 31 (2019) e1904278 doi: 10.1002/adma.201904278
30. [30]
  C.R. Thomas, D.P. Ferris, J.H. Lee, et al., J. Am. Chem. Soc. 132 (2010) 10623-10625 doi: 10.1021/ja1022267
31. [31]
  Z. Zhang, L. Wang, J. Wang, et al., Adv. Mater. 24 (2012) 1418-1423 doi: 10.1002/adma.201104714
32. [32]
  C. Qi, Y.J. Zhu, X.Y. Zhao, et al., Mater. Res. Bull. 48 (2013) 1536-1540 doi: 10.1016/j.materresbull.2012.12.052
33. [33]
  Z. Shi, Q. Li, L. Mei, Chin. Chem. Lett. 31 (2020) 1345-1356 doi: 10.1016/j.cclet.2020.03.001
34. [34]
  Y. Qiu, Y. Liu, L. Wang, et al., Biomaterials31 (2010) 7606-7619 doi: 10.1016/j.biomaterials.2010.06.051
35. [35]
  Y. Yang, Y. Lin, D. Di, et al., J. Colloid Interface Sci. 508 (2017) 323-331 doi: 10.1016/j.jcis.2017.08.050
36. [36]
  J.L. Vivero-Escoto, I.I. Slowing, C.W. Wu, V.S. Lin, J. Am. Chem. Soc. 131 (2009) 3462-3463 doi: 10.1021/ja900025f
37. [37]
  M. Shourian, H. Ghourchian, M. Boutorabi, Anal. Chim. Acta895 (2015) 1-11 doi: 10.1016/j.aca.2015.07.013
38. [38]
  R. Cheng, F. Feng, F. Meng, et al., J. Control. Release152 (2011) 2-12 doi: 10.1016/j.jconrel.2011.01.030
39. [39]
  G. Saito, J.A. Swanson, K.D. Lee, Adv. Drug Deliv. Rev. 55 (2003) 199-215 doi: 10.1016/S0169-409X(02)00179-5
40. [40]
  P. Eskandari, B. Bigdeli, M. Porgham Daryasari, et al., J. Drug Target. 27 (2019) 1084-1093 doi: 10.1080/1061186x.2019.1599379
41. [41]
  L. Zhu, P. Kate, V.P. Torchilin, ACS Nano6 (2012) 3491-3498 doi: 10.1021/nn300524f
42. [42]
  Y. Wang, S. Song, J. Liu, et al., Angew. Chem. Int. Ed. 54 (2015) 536-540
43. [43]
  M. Liu, X. Sun, Z. Liao, et al., Drug Deliv. 26 (2019) 732-743 doi: 10.1080/10717544.2019.1642419
44. [44]
  F. Muhammad, M. Guo, W. Qi, et al., J. Am. Chem. Soc. 133 (2011) 8778-8781 doi: 10.1021/ja200328s
45. [45]
  X. Fang, T. Zhai, U.K. Gautam, et al., Prog. Mater. Sci. 56 (2011) 175-287 doi: 10.1016/j.pmatsci.2010.10.001
46. [46]
  Y. Salinas, C. Hoerhager, A. Garcia-Fernandez, et al., ACS Appl. Mater. Interfaces10 (2018) 34029-34038 doi: 10.1021/acsami.8b13698
47. [47]
  Y. Sun, L. Zheng, Y. Yang, et al., Nano Micro Lett. 12 (2020) 103 doi: 10.1007/978-981-15-7056-8_7
48. [48]
  S. Zhang, X. Pei, H. Gao, et al., Chin. Chem. Lett. 31 (2020) 1060-1070 doi: 10.1016/j.cclet.2019.11.036
49. [49]
  X. Qian, S. Deng, X. Chen, et al., Chin. Chem. Lett. 31 (2020) 2211-2214 doi: 10.1016/j.cclet.2019.09.024
50. [50]
  S. Rojas, F.J. Carmona, C.R. Maldonado, et al., Inorg. Chem. 55 (2016) 2650-2663 doi: 10.1021/acs.inorgchem.6b00045
51. [51]
  H. Zhang, W. Jiang, R. Liu, et al., ACS Appl. Mater. Interfaces9 (2017) 19687-19697 doi: 10.1021/acsami.7b05142
52. [52]
  C. Adhikari, A. Mishra, D. Nayak, A. Chakraborty, J. Drug Deliv. Sci. Technol. 47 (2018) 1-11 doi: 10.1016/j.jddst.2018.06.015
53. [53]
  L. Guo, I. Panderi, D.D. Yan, et al., ACS Nano7 (2013) 8780-8793 doi: 10.1021/nn403202w
54. [54]
  L. An, X. Wang, X. Rui, et al., Angew. Chem. Int. Ed. 57 (2018) 15782-15786 doi: 10.1002/anie.201810082
55. [55]
  M. Zhang, X. Liu, Q. Luo, et al., Chem. Eng. J. 389 (2020) 124450 doi: 10.1016/j.cej.2020.124450
56. [56]
  Q. Wei, Y. Chen, X. Ma, et al., Adv. Funct. Mater. 28 (2017) 1704634
57. [57]
  X. Cheng, D. Li, A. Lin, et al., Int. J. Nanomed. 13 (2018) 3661-3677 doi: 10.2147/ijn.s167407
58. [58]
  H. Liang, B. Zhou, D. Wu, et al., Adv. Colloid Interface Sci. 272 (2019) 102019 doi: 10.1016/j.cis.2019.102019
59. [59]
  T.S. Sileika, D.G. Barrett, R. Zhang, et al., Angew. Chem. Int. Ed. 52 (2013) 10766-10770 doi: 10.1002/anie.201304922
60. [60]
  H. Ejima, J.J. Richardson, K. Liang, et al., Science341 (2013) 154-157 doi: 10.1126/science.1237265
61. [61]
  C. Park, B.J. Yang, K.B. Jeong, et al., Angew. Chem. Int. Ed. 56 (2017) 5485-5489 doi: 10.1002/anie.201701152
62. [62]
  B. Yang, S. Zhou, J. Zeng, et al., Nano Res. 13 (2020) 1013-1019 doi: 10.1007/s12274-020-2736-6
63. [63]
  A.F. Moreira, V.M. Gaspar, E.C. Costa, et al., Eur. J. Pharm. Biopharm. 88 (2014) 1012-1025 doi: 10.1016/j.ejpb.2014.09.002
64. [64]
  A.D. Trofimov, A.A. Ivanova, M.V. Zyuzin, A.S. Timin, Pharmaceutics10 (2018)167 doi: 10.3390/pharmaceutics10040167
65. [65]
  P. Srivastava, S.K. Hira, D.N. Srivastava, et al., ACS Appl. Mater. Interfaces10 (2018) 6917-6929 doi: 10.1021/acsami.7b18729
66. [66]
  Y. He, B. Zeng, S. Liang, et al., ACS Appl. Mater. Interfaces9 (2017) 44402-44409 doi: 10.1021/acsami.7b16787
67. [67]
  J. Ma, H. Wu, Y. Li, et al., Pharm. Res. 35 (2018) 57 doi: 10.1134/s0424857018110063
68. [68]
  G. Crini, Chem. Rev. 114 (2014) 10940-10975 doi: 10.1021/cr500081p
69. [69]
  Y.M. Zhang, Y.H. Liu, Y. Liu, Adv. Mater. 32 (2020) e1806158 doi: 10.1002/adma.201806158
70. [70]
  B. Schmidt, C. Barner-Kowollik, Angew. Chem. Int. Ed. 56 (2017) 8350-8369 doi: 10.1002/anie.201612150
71. [71]
  J.J. Hu, Q. Lei, M.Y. Peng, et al., Biomaterials128 (2017) 136-146 doi: 10.1001/jamainternmed.2016.7068
72. [72]
  Y. Wu, Z. Xu, W. Sun, et al., Mater. Sci. Eng. C Mater. Biol. Appl. 103 (2019) 109831 doi: 10.1016/j.msec.2019.109831
73. [73]
  A. Llopis-Lorente, A. Garcia-Fernandez, N. Murillo-Cremaes, et al., ACS Nano13 (2019) 12171-12183 doi: 10.1021/acsnano.9b06706
74. [74]
  M. Dash, F. Chiellini, R.M. Ottenbrite, E. Chiellini, Prog. Polym. Sci. 36 (2011) 981-1014 doi: 10.1016/j.progpolymsci.2011.02.001
75. [75]
  R. Jayakumar, M. Prabaharan, S.V. Nair, H. Tamura, Biotechnol. Adv. 28 (2010) 142-150 doi: 10.1016/j.biotechadv.2009.11.001
76. [76]
  H. Yi, L.Q. Wu, W.E. Bentley, et al., Biomacromolecules6 (2005) 2881-2894 doi: 10.1021/bm050410l
77. [77]
  M.N. Kumar, R.A. Muzzarelli, C. Muzzarelli, et al., Chem. Rev. 104 (2004) 6017-6084 doi: 10.1021/cr030441b
78. [78]
  T. Yan, J. He, R. Liu, et al., Carbohydr. Polym. 231 (2020) 115706 doi: 10.1016/j.carbpol.2019.115706
79. [79]
  B.P. Toole, Nat. Rev. Cancer4 (2004) 528-539 doi: 10.1038/nrc1391
80. [80]
  R. Stern, M.J. Jedrzejas, Chem. Rev. 106 (2006) 818-839 doi: 10.1021/cr050247k
81. [81]
  G. Tripodo, A. Trapani, M.L. Torre, et al., Eur. J. Pharm. Biopharm. 97 (2015) 400-416 doi: 10.1016/j.ejpb.2015.03.032
82. [82]
  Q. Zhao, S. Wang, Y. Yang, et al., Mater. Sci. Eng. C Mater. Biol. Appl. 78 (2017) 475-484 doi: 10.1016/j.msec.2017.04.059
83. [83]
  W. Ma, Q. Chen, W. Xu, et al., Nano Res. 14 (2020) 846-857 doi: 10.1109/ei250167.2020.9347325
84. [84]
  J. Meng, Z. Jin, P. Zhao, et al., Sci. Adv. 6 (2020) eaba1362 doi: 10.1126/sciadv.aba1362
85. [85]
  A.B. Cook, S. Perrier, Adv. Funct. Mater. 30 (2019) 1901001
86. [86]
  M. He, L. Yu, Y. Yang, et al., Chin. Chem. Lett. 31 (2020) 3178-3182 doi: 10.1016/j.cclet.2020.05.034
87. [87]
  Z. Li, X. Shan, Z. Chen, et al., Adv. Sci. (Weinh. )8 (2020) 2002589
88. [88]
  Y. Zhang, C.Y. Ang, M. Li, et al., ACS Appl. Mater. Interfaces7 (2015) 18179-18187 doi: 10.1021/acsami.5b05893
89. [89]
  H. Peng, R. Dong, S. Wang, et al., Int. J. Pharm. 446 (2013) 153-159 doi: 10.1016/j.ijpharm.2013.01.071
90. [90]
  P.W. Chung, R. Kumar, M. Pruski, V.S.Y. Lin, Adv. Funct. Mater. 18 (2008) 1390-1398 doi: 10.1002/adfm.200701116
91. [91]
  A. Kienzle, S. Kurch, J. Schloder, et al., Adv. Healthc. Mater. 6 (2017) 1700012 doi: 10.1002/adhm.201700012
92. [92]
  L. Chen, T. Zhao, M. Zhao, et al., Chem. Sci. 11 (2020) 2819-2827 doi: 10.1039/c9sc06260b
93. [93]
  L. Li, W. Sun, L. Li, et al., Nanoscale9 (2017) 314-325 doi: 10.1039/C6NR07004C
94. [94]
  S. Mu, Y. Liu, T. Wang, et al., Acta Biomater. 63 (2017) 150-162 doi: 10.1016/j.actbio.2017.08.050
95. [95]
  D. Wu, Z.Q. Zhu, H.X. Tang, et al., Theranostics10 (2020) 9808-9829 doi: 10.7150/thno.43631
96. [96]
  Q. Yan, X. Guo, X. Huang, et al., ACS Appl. Mater. Interfaces11 (2019) 24377-24385 doi: 10.1021/acsami.9b04142
97. [97]
  W. Cheng, X. Zeng, H. Chen, et al., ACS Nano13 (2019) 8537-8565 doi: 10.1021/acsnano.9b04436
98. [98]
  W. Wang, Z. Tang, Y. Zhang, et al., Macromol. Biosci. 20 (2020) e2000222 doi: 10.1002/mabi.202000222
99. [99]
  H. Lee, S.M. Dellatore, W.M. Miller, P.B. Messersmith, Science318 (2007) 426-430 doi: 10.1126/science.1147241
100. [100]
  W. Cheng, J. Nie, L. Xu, et al., ACS Appl. Mater. Interfaces9 (2017) 18462-18473 doi: 10.1021/acsami.7b02457
101. [101]
  D. Chang, Y. Gao, L. Wang, et al., J. Colloid Interface Sci. 463 (2016) 279-287 doi: 10.1016/j.jcis.2015.11.001
102. [102]
  W. Cheng, C. Liang, L. Xu, et al., Small13 (2017) 1700623 doi: 10.1002/smll.201700623
103. [103]
  Y. Yang, W. Zeng, P. Huang, et al., View2 (2020) 20200042
104. [104]
  W. Cheng, J. Nie, N. Gao, et al., Adv. Funct. Mater. 27 (2017) 1704135 doi: 10.1002/adfm.201704135
105. [105]
  K. Li, C. Lin, Y. He, et al., ACS Nano14 (2020) 14164-14180 doi: 10.1021/acsnano.0c07071
106. [106]
  H. Zhang, Q. Xia, D. Zhou, Colloids Surf. B Biointerfaces193 (2020) 111107 doi: 10.1016/j.colsurfb.2020.111107
107. [107]
  X. Chen, H. Sun, J. Hu, et al., Colloids Surf. B Biointerfaces152 (2017) 77-84 doi: 10.1016/j.colsurfb.2017.01.010
108. [108]
  R. Bhat, I. Garcia, E. Aznar, et al., Nanoscale10 (2017) 239-249 doi: 10.31142/ijtsrd5940
109. [109]
  B. Zhang, Z. Luo, J. Liu, et al., J. Control. Release192 (2014) 192-201 doi: 10.1016/j.jconrel.2014.06.037
110. [110]
  R.R. Castillo, A. Baeza, M. Vallet-Regi, Biomater. Sci. 5 (2017) 353-377 doi: 10.1039/C6BM00872K
111. [111]
  L. Pascual, C. Cerqueira-Coutinho, A. Garcia-Fernandez, et al., Nanomedicine13 (2017) 2495-2505 doi: 10.1016/j.nano.2017.08.006
112. [112]
  À. Ribes, S. Santiago-Felipe, A. Aviñó, et al., Sens. Actuators B Chem. 277 (2018) 598-603 doi: 10.1016/j.snb.2018.09.026
113. [113]
  X. Zeng, G. Liu, W. Tao, et al., Adv. Funct. Mater. 27 (2017) 1605985 doi: 10.1002/adfm.201605985
114. [114]
  C. Liang, H. Wang, M. Zhang, et al., J. Colloid Interface Sci. 525 (2018) 1-10 doi: 10.1016/j.jcis.2018.04.058
115. [115]
  W. Cheng, C. Liang, X. Wang, et al., Nanoscale9 (2017) 17063-17073 doi: 10.1039/C7NR05450E
116. [116]
  Z. Wang, F. Zhang, D. Shao, et al., Adv. Sci. (Weinh. )6 (2019) 1901690 doi: 10.1002/advs.201901690
117. [117]
  X. Liang, X. Ye, C. Wang, et al., J. Control. Release296 (2019) 150-161 doi: 10.1016/j.jconrel.2019.01.027
118. [118]
  J. Su, H. Sun, Q. Meng, et al., Theranostics7 (2017) 523-537 doi: 10.7150/thno.17259
119. [119]
  D. Zhang, Z. Lin, Y. Zheng, et al., ACS Nano14 (2020) 8985-8999 doi: 10.1021/acsnano.0c03833
120. [120]
  D. Nie, Z. Dai, J. Li, et al., Nano Lett. 20 (2020) 936-946 doi: 10.1021/acs.nanolett.9b03817
121. [121]
  D. Shao, F. Zhang, F. Chen, et al., Adv. Mater. 32 (2020) e2004385 doi: 10.1002/adma.202004385
122. [122]
  Z.A. Chen, S.H. Wu, P. Chen, et al., ACS Appl. Mater. Interfaces11 (2019) 4790-4798 doi: 10.1021/acsami.8b18434
1. [1]
  Jiaxu Wang , Jinxie Zhang , Xiuping Wang , Jingying Wang , Lina Chen , Jiahui Cao , Wei Cao , Siyu Liang , Ping Luan , Ke Zheng , Xiao-Kun Ouyang , Li Gao , Xiaowen Ou , Fan Zhang , Meitong Ou , Lin Mei . CaCO₃-coated hollow mesoporous silica nanoparticles for pH-responsive fungicides release. Chinese Chemical Letters, 2024, 35(12): 109697-. doi: 10.1016/j.cclet.2024.109697
2. [2]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
3. [3]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
4. [4]
  Wantong Zhang , Zixing Xu , Guofei Dai , Zhijian Li , Chunhui Deng . Removal of Microcystin-LR in lake water sample by hydrophilic mesoporous silica composites under high-throughput MALDI-TOF MS detection platform. Chinese Chemical Letters, 2024, 35(5): 109135-. doi: 10.1016/j.cclet.2023.109135
5. [5]
  Haobo Wang , Fei Wang , Yong Liu , Zhongxiu Liu , Yingjie Miao , Wanhong Zhang , Guangxin Wang , Jiangtao Ji , Qiaobao Zhang . Emerging natural clay-based materials for stable and dendrite-free lithium metal anodes: A review. Chinese Chemical Letters, 2025, 36(2): 109589-. doi: 10.1016/j.cclet.2024.109589
6. [6]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
7. [7]
  Rui Li , Ruijie Lu , Libin Yang , Jianwen Li , Zige Guo , Qiquan Yan , Mengjun Li , Yazhuo Ni , Keying Chen , Yaoyang Li , Bo Xu , Mengzhen Cui , Zhan Li , Zhiying Zhao . Immobilization of chitosan nano-hydroxyapatite alendronate composite microspheres on polyetheretherketone surface to enhance osseointegration by inhibiting osteoclastogenesis and promoting osteogenesis. Chinese Chemical Letters, 2025, 36(4): 110242-. doi: 10.1016/j.cclet.2024.110242
8. [8]
  Makhloufi Zoulikha , Zhongjian Chen , Jun Wu , Wei He . Approved delivery strategies for biopharmaceuticals. Chinese Chemical Letters, 2025, 36(2): 110225-. doi: 10.1016/j.cclet.2024.110225
9. [9]
  Jing Zhang , Charles Wang , Yaoyao Zhang , Haining Xia , Yujuan Wang , Kun Ma , Junfeng Wang . Application of magnetotactic bacteria as engineering microrobots: Higher delivery efficiency of antitumor medicine. Chinese Chemical Letters, 2024, 35(10): 109420-. doi: 10.1016/j.cclet.2023.109420
10. [10]
  Tong Tong , Lezong Chen , Siying Wu , Zhong Cao , Yuanbin Song , Jun Wu . Establishment of a leucine-based poly(ester amide)s library with self-anticancer effect as nano-drug carrier for colorectal cancer treatment. Chinese Chemical Letters, 2024, 35(12): 109689-. doi: 10.1016/j.cclet.2024.109689
11. [11]
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12. [12]
  Jianwen Zhao , Shuai Wang , Shanshan Zhao , Liwei Chen , Fangang Meng , Xuelin Tian . A non-fluorinated liquid-like membrane with excellent anti-scaling performance for membrane distillation. Chinese Chemical Letters, 2025, 36(1): 109883-. doi: 10.1016/j.cclet.2024.109883
13. [13]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
14. [14]
  Yong-Dan Zhao , Yidan Wang , Rongrong Wang , Lina Chen , Hengtong Zuo , Xi Wang , Jihong Qiang , Geng Wang , Qingxia Li , Canqi Ping , Shuqiu Zhang , Hao Wang . Reversing artemisinin resistance by leveraging thermo-responsive nanoplatform to downregulating GSH. Chinese Chemical Letters, 2024, 35(6): 108929-. doi: 10.1016/j.cclet.2023.108929
15. [15]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
16. [16]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
17. [17]
  Yinglan Yu , Sajid Hussain , Jianping Qi , Lei Luo , Xuemei Zhang . Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells. Chinese Chemical Letters, 2024, 35(12): 109673-. doi: 10.1016/j.cclet.2024.109673
18. [18]
  Han Wu , Yumei Wang , Zekai Ren , Hailin Cong , Youqing Shen , Bing Yu . The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy. Chinese Chemical Letters, 2025, 36(4): 109996-. doi: 10.1016/j.cclet.2024.109996
19. [19]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
20. [20]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576

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沈阳化工大学材料科学与工程学院沈阳 110142