Citation: Liqiang Hao, Hongyan Liu, Zheng Zhang, Fuqiang Wen, Chengcai Xia, Zengfen Pang. Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C–C/C–N formation, annulation and aromatization with 1, 2-dichloroethane[J]. Chinese Chemical Letters, ;2021, 32(7): 2309-2312. doi: 10.1016/j.cclet.2021.02.025 shu

Cascade reaction to 1H-pyrazoles from hydrazones via sodium Ni-trite promoted dual C–C/C–N formation, annulation and aromatization with 1, 2-dichloroethane

Liqiang Hao ^a ,
Hongyan Liu ^a ,
Zheng Zhang ^a ,
Fuqiang Wen ^a ,
Chengcai Xia ^{a, *,} ,
Zengfen Pang ^{b, *,}

a.
Institute of Pharmacology, Pharmacy College, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China
b.
Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250117, China

xiachc@163.com

pangzf0806@163.com

Received Date: 8 December 2020
Revised Date: 2 February 2021
Accepted Date: 9 February 2021
Available Online: 15 February 2021

Figures(5)

A novel route for tandem C–C/C–N formation, annulation and aromatization of hydrazones with 1, 2-dichloroethane to synthesize 1H-pyrazoles has been developed. Furthermore, the 1, 2-dichloroethane serves as alkylation reagent in good to excellent yields. This methodology features mild reaction conditions and good functional group tolerance, providing a direct approach for the preparation of 1H-pyrazoles.
- Tandem,
- Hydrazones,
- 1, 2-Dichloroethane,
- 1H-pyrazoles,
- Annulation
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