Citation: Zhang-Ye Han, Hong-Kai Li, Qian-Qian Zhu, Rongrong Yuan, Hongming He. An intriguing electrochemical impedance aptasensor based on a porous organic framework supported silver nanoparticles for ultrasensitively detecting theophylline[J]. Chinese Chemical Letters, ;2021, 32(9): 2865-2868. doi: 10.1016/j.cclet.2021.02.013 shu

An intriguing electrochemical impedance aptasensor based on a porous organic framework supported silver nanoparticles for ultrasensitively detecting theophylline

a.
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China
b.
Department of Materials Science and Engineering, Jilin Jianzhu University, Changchun 130118, China

Corresponding author: Hongming He, hehongminghz@163.com
Received Date: 25 November 2020
Revised Date: 4 January 2021
Accepted Date: 6 February 2021
Available Online: 9 February 2021

Figures(4)

Porous organic frameworks (POFs) are excellently stable porous materials, which can be employed as host platforms to support metal nanoparticles as functional composites for various applications. Herein, a novel POF is successfully prepared via Friedel-Crafts reaction. Silver nanoparticles (Ag NPs) are embedded in the prepared POF to generate an Ag@POF composite, which not only possesses high surface area, outstanding physicochemical stability and outstretched π-conjugation skeleton, but also exhibits preferable electrochemical stability and conductivity. This composite is able to immobilize a mass of aptamer strands to fabricate an intriguing electrochemical aptasensor. Electrochemical impedance spectroscopy (EIS) is a commonly used technology to analyze the electrochemical signal variation. The Ag@POF-based biosensor shows the excellent electrochemical detection behavior through analyzing EIS. For instance theophylline as a research mode, the Ag@POF based electrochemical aptasensor reveals ultra-sensitiveness, high selectivity, remarkable stability, good repeatability and simple operability even in various real samples. Notably, this aptasensor has the sensitive detection performance with the limit of detection of 0.191 pg/mL (1.06 pmol/L) in a wide concentration range of 5.0 × 10^-4 – 5.0 ng/mL (2.78 × 10^-3 – 27.8 nmol/L).
- Ag@POF composite,
- Aptamer,
- Electrochemical aptasensor,
- Theophylline,
- Sensitive detection
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