Citation: Yonghui Liu, Mingjing Li, Haomiao Zhu, Zhe Jing, Xiaona Yin, Kun Wang, Zhangyong Hong, Wei Zhao. Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine[J]. Chinese Chemical Letters, ;2021, 32(6): 1963-1966. doi: 10.1016/j.cclet.2021.01.035 shu

Alum colloid encapsulated inside β-glucan particles enhance humoral and CTL immune responses of MUC1 vaccine

Yonghui Liu ^a ,
Mingjing Li ^a ,
Haomiao Zhu ^a ,
Zhe Jing ^b ,
Xiaona Yin ^a ,
Kun Wang ^a ,
Zhangyong Hong ^{b, *,} ,
Wei Zhao ^{a, *,}

a.
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and KLMDASR of Tianjin, Nankai University, Tianjin 300353, China
b.
State Key Laboratory of Medicinal Chemical Biology & Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin 300071, China

hongzy@nankai.edu.cn@126.com

wzhao@nankai.edu.cn

Received Date: 3 December 2020
Revised Date: 18 January 2021
Accepted Date: 19 January 2021
Available Online: 27 January 2021

Figures(6)

We have developed a MUC1 antigen-based antitumor vaccine loaded on alum colloid encapsulated inside β-glucan particles (GP-Al). The constructed vaccine induced strong MUC1 antigen specific IgG antibody titers and enhanced CD8⁺ T cells cytotoxic effect to kill tumor cells. These results indicated that GP-Al can be served as an efficient delivery system and adjuvant for the development of cancer vaccines especially small molecule antigens based cancer vaccines.
- MUC 1 antigen,
- Glycopeptide,
- GP-Al,
- Adjuvant,
- Antitumor vaccine
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