Citation: Jun Huang, Xinru You, Peikun Xin, Zhipeng Gu, Chun Chen, Jun Wu. Egg white as a natural and safe biomaterial for enhanced cancer therapy[J]. Chinese Chemical Letters, ;2021, 32(5): 1737-1742. doi: 10.1016/j.cclet.2020.12.006 shu

Egg white as a natural and safe biomaterial for enhanced cancer therapy

Jun Huang ^a ,
Xinru You ^a ,
Peikun Xin ^b ,
Zhipeng Gu ^c ,
Chun Chen ^{a, *} ,
Jun Wu ^{a, b, *}

a.
Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, China
b.
School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China
c.
College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China

chenchun69@126.com

wujun29@mail.sysu.edu.cn

Received Date: 9 October 2020
Revised Date: 4 December 2020
Accepted Date: 11 December 2020
Available Online: 11 December 2020

Figures(7)

The last few decades have witnessed the emergence of a very large variety of engineered nanomaterials. However, it is far from to meet the growing clinical demand. Actually, nature itself is an excellent nanotechnologist, and provides us with a range of wonderful materials, from inorganic particles found in non-life bodies to biofilms, like platelets, erythrocyte membranes, produced by many bacteria or cells. These nanomaterials are entirely natural, and not surprisingly, there is a growing interest in the development of natural nanoproducts. Native components-inspired biomaterials have gained considerable attention owing to their safety and functions. In this study, egg white was developed as drug carrier to load PTX by a green and simple one-pot method, and systematic characterization was completed. The results indicated that PTX@EW NPs possess excellent biocompatibility, enhanced tumor targeting capability, effectively reducing the toxic side effects of PTX. The obviously enhanced antitumor effect further confirmed EW was a highly prospective biomaterial in the nano-carrier industry.
- Egg white,
- Natural biomaterial,
- Nanocarrier,
- Biosafe,
- Antitumor
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