Citation: Panpan Pan, Xiao Chen, Huaran Xing, Yonghui Deng, Jingdi Chen, Fahad A. Alharthi, Abdulaziz A. Alghamdi, Jiacan Su. A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction[J]. Chinese Chemical Letters, ;2021, 32(7): 2159-2163. doi: 10.1016/j.cclet.2020.12.001 shu

A fast on-demand preparation of injectable self-healing nanocomposite hydrogels for efficient osteoinduction

Panpan Pan ^{a, c, 1} ,
Xiao Chen ^{b, 1} ,
Huaran Xing ^d ,
Yonghui Deng ^{a, f, *,} ,
Jingdi Chen ^{d, **,} ,
Fahad A. Alharthi ^e ,
Abdulaziz A. Alghamdi ^e ,
Jiacan Su ^{b, **,}

a.
Department of Chemistry, Department of Gastroenterology, Zhongshan Hospital of Fudan University, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China
b.
Department of Orthopaedics Trauma, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
c.
Institute of Biomedical and Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, China
d.
Marine College, Shandong University, Weihai 264209, China
e.
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
f.
State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China

^**

yhdeng@fudan.edu.cn

021044069@fudan.edu.cn

jdchen@sdu.edu.cn

drsujiacan@163.com

Received Date: 5 November 2020
Revised Date: 30 November 2020
Accepted Date: 2 December 2020
Available Online: 4 December 2020

Figures(5)

Injectable hydrogels have been considered as promising materials for bone regeneration, but their osteoinduction and mechanical performance are yet to be improved. In this study, a novel biocompatible injectable and self-healing nano hybrid hydrogel was on-demand prepared via a fast (within 30 s) and easy gelation approach by reversible Schiff base formed between −CH=O of oxidized sodium alginate (OSA) and −NH₂ of glycol chitosan (GCS) mixed with calcium phosphate nanoparticles (CaP NPs). Its raw materials can be ready in large quantities by a simple synthesis process. The mechanical strength, degradation and swelling behavior of the hydrogel can be readily controlled by simply controlling the molar ratio of −CH=O and −NH₂. This hydrogel exhibits pH responsiveness, good degradability and biocompatibility. The hydrogel used as the matrix for mesenchymal stem cells can significantly induce the proliferation, differentiation and osteoinduction in vitro. These results showed this novel hydrogel is an ideal candidate for applications in bone tissue regeneration and drug delivery.
- Dynamic coordination,
- Nanocomposite hydrogels,
- Fast and easy on-demand preparation,
- Injectable and self-healing abilities,
- Stem cell osteoinduction
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