Citation: Mingkai Chen, Xiaoting Huang, Jie Lai, Li Ma, Tianfeng Chen. Substituent-regulated highly X-ray sensitive Os(Ⅵ) nitrido complex for low-toxicity radiotherapy[J]. Chinese Chemical Letters, ;2021, 32(1): 158-161. doi: 10.1016/j.cclet.2020.11.050 shu

Substituent-regulated highly X-ray sensitive Os(Ⅵ) nitrido complex for low-toxicity radiotherapy

Department of Chemistry, Jinan University, Guangzhou 510632, China

chem_mali@jnu.edu.cn

tchentf@jnu.edu.cn

Received Date: 10 September 2020
Revised Date: 21 November 2020
Accepted Date: 23 November 2020
Available Online: 30 November 2020

Figures(4)

A high efficiency and low toxicity radiosensitizer, OsN(PhenOH)Cl₃, was designed and synthesized through substituent regulation. To the best of our knowledge, this is the first osmium-based coordination complex radiosensitizer. The experimental results shown that this radiosensitizer induced G2/M cell cycle arrest mainly through induction of intracellular ROS overproduction.
- Os(Ⅵ) nitrido,
- Complex,
- Radiotherapy,
- Radiosensitizer,
- G2/M cell cycle arrest
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