Citation: Yufen Li, Songwei Li, Cristina Cuadrado, Chenglong Gao, Qihao Wu, Xiaolu Li, Tao Pang, Antonio Hernandez Daranas, Yuewei Guo, Xuwen Li. Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry[J]. Chinese Chemical Letters, ;2021, 32(1): 271-276. doi: 10.1016/j.cclet.2020.11.037 shu

Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry

Yufen Li ^{a, 1} ,
Songwei Li ^{a, b, 1} ,
Cristina Cuadrado ^{c, 1} ,
Chenglong Gao ^d ,
Qihao Wu ^a ,
Xiaolu Li ^a ,
Tao Pang ^d ,
Antonio Hernandez Daranas ^{c, *,} ,
Yuewei Guo ^{a, *,} ,
Xuwen Li ^{a, *,}

a.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
b.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China
c.
Instituto de Productos Naturales y Agrobiologi'a, Consejo Superior de Investigaciones Científicas (IPNA-CSIC), La Laguna 38206, Spain
d.
Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing, 210009 China

adaranas@ull.edu.es

ywguo@simm.ac.cn

xwli@simm.ac.cn

Received Date: 25 September 2020
Revised Date: 27 October 2020
Accepted Date: 16 November 2020
Available Online: 23 November 2020

Figures(7)

Five novel biscembranoids, ximaolides H–L (1–5), along with four known related compounds (6–9) were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of the new compounds were determined by extensive spectroscopic analysis, quantum chemical calculations, and/or by comparing their CD spectra with those of the known compounds. Compounds 1 and 2 are the first examples of biscembranoids bearing a 1,35-bridged lactone moiety, 4 is the first biscembranoid comprising an uncommon oxetane ring, and 5 represents the first 36-peroxyl biscembranoid. Ximaolides I (2), K (4) and F (9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-α protein release in RAW264.7 macrophages.
- Soft coral,
- Sarcophyton tortuosum,
- Biscembranoid,
- Stereochemistry,
- Anti-inflammatory
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