Citation: Keqing Huang, Guiting Liu, Zhipeng Gu, Jun Wu. Tofu as excellent scaffolds for potential bone regeneration[J]. Chinese Chemical Letters, ;2020, 31(12): 3190-3194. doi: 10.1016/j.cclet.2020.07.002 shu

Tofu as excellent scaffolds for potential bone regeneration

Keqing Huang ^{a, b, 1} ,
Guiting Liu ^{a, b, 1} ,
Zhipeng Gu ^{b, c, *,} ,
Jun Wu ^{a, b, *,}

a.
Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China
b.
Research Institute of Sun Yat-sen University in Shenzhen, Shenzhen 518057, China
c.
College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China

guzhipeng2019@scu.edu.cn

wujun29@mail.sysu.edu.cn

Received Date: 10 May 2020
Revised Date: 28 June 2020
Accepted Date: 1 July 2020
Available Online: 1 July 2020

Figures(3)

Biomimetic scaffolds present the promising potential for bone regeneration. As a natural gel-like traditional food, tofu with porous architecture and proved biological safety indicated a good potential to be a natural scaffold and easy to be improved by surface modification. Hereon, we fabricated the tofubased scaffolds and systematically explored the potential for bone tissue engineering. In addition, the collagen has been introduced by simple coating to further enhance the surface compatibility of the tofubased scaffold in bone regeneration. The results showed that the tofu-based scaffolds possessed good porous structure and cytocompatibility. Notably, the tofu-based scaffolds could improve the expression of osteogenesis-related genes and proteins, leading to better bone regeneration after 2 months of implantation. All the results indicated that tofu would become an outstanding sustainable natural porous scaffold for bone regeneration with excellent bioactivities.
- Bone regeneration,
- Scaffolds,
- Tofu,
- Collagen,
- Macrophages
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