Citation: Shengke Li, Yan Gao, Yuanfu Ding, Anni Xu, Huaping Tan. Supramolecular nano drug delivery systems mediated via host-guest chemistry of cucurbit[n]uril (n = 6 and 7)[J]. Chinese Chemical Letters, ;2021, 32(1): 313-318. doi: 10.1016/j.cclet.2020.04.049 shu

Supramolecular nano drug delivery systems mediated via host-guest chemistry of cucurbit[n]uril (n = 6 and 7)

Shengke Li ^{a, *,1,} ,
Yan Gao ^{b, 1} ,
Yuanfu Ding ^b ,
Anni Xu ^a ,
Huaping Tan ^a

a.
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
b.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China

Author Bio: Dr. Shengke Li received MSc degree in Organic Chemistry from East China University of Science and Technology in 2012. After three years working as a Chemist in cosmetic industry, he joined University of Macau to pursue Ph.D. degree in Biomedical Sciences under the supervision of Professor Ruibing Wang in 2015. Since then, he focused on pharmaceutical applications of cucurbituril-based hostguest chemistry. After graduation in 2018, he joined Nanjing University of Science and Technology as a Lecturer and continued his research on supramolecular biomaterials based on cucurbiturils and their derivatives.

lisk@njust.edu.cn

Received Date: 12 March 2020
Revised Date: 15 April 2020
Accepted Date: 27 April 2020
Available Online: 5 May 2020

Figures(4)

As a novel family of macrocyclic molecules, cucurbit[n]urils (CB[n]s) have emerged as promising building blocks of supramolecular nano drug delivery systems (SNDDS) in recent years. Direct encapsulation of amphiphilic guests by CB[6] and CB[7] can modulate their amphiphilicity, resulting in formation of supramolecular amphiphiles that self-assemble into supramolecular nanoparticles for drug delivery. Additionally, CB[n]'s host-guest chemistry on the surface of mesoporous nanoparticles makes CB[n] an ideal blocking agent to control drug release from delivery vehicles. These SNDDS possess intrinsic stimuli responsiveness towards external guest or host, which can further incorporate responsiveness to a variety of other stimuli including pH, thermal, redox, photo and enzyme, to realize multiple stimuli-responsive drug release. Moreover, the recent breakthrough in direct functionalization of CB[n]s has provided a feasible method for preparing superior CB[6] and CB[7] derivatives that can be employed to build multifunctional SNDDS with unoccupied macrocycles located on surface, which could be decorated with various functional "tags" through host-guest chemistry. In this review, we summarized the recent progress of CB[6] and CB[7] based SNDDS through formation of supramolecular amphiphiles, supramolecular nanovalves as well as supramolecularly tailorable surface, which we hope to further promote the development of CB[n]s family as building blocks for advanced SNDDS.
- Cucurbit[n]uril,
- Host-guest chemistry,
- Self-assembly,
- Nano,
- Drug delivery,
- Stimuli-responsive
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