Citation: Anman Zhang, Luo Hai, Tianzheng Wang, Hong Cheng, Man Li, Xiaoxiao He, Kemin Wang. NIR-triggered drug delivery system based on phospholipid coated ordered mesoporous carbon for synergistic chemo-photothermal therapy of cancer cells[J]. Chinese Chemical Letters, ;2020, 31(12): 3158-3162. doi: 10.1016/j.cclet.2020.04.035 shu

NIR-triggered drug delivery system based on phospholipid coated ordered mesoporous carbon for synergistic chemo-photothermal therapy of cancer cells

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, State Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha 410082, China

xiaoxiaohe@hnu.edu.cn

kmwang@hnu.edu.cn

Received Date: 4 March 2020
Revised Date: 20 April 2020
Accepted Date: 21 April 2020
Available Online: 24 April 2020

Figures(4)

Chemo-photothermal treatment is one of the most efficient strategies for cancer therapy. However, traditional drug carriers without near-infrared absorption capacity need to be loaded with materials behaving photothermal properties, as it results in complicated synthesis process, inefficient photothermal effects and hindered NIR-mediated drug release. Herein we report a facile synthesis of a polyethylene glycol (PEG) linked liposome (PEG-liposomes) coated doxorubicin (DOX)-loaded ordered mesoporous carbon (OMC) nanocomponents (PEG-LIP@OMC/DOX) by simply sonicating DOX and OMC in PEG-liposomes suspensions. The as-obtained PEG-LIP@OMC/DOX exhibits a nanoscale size (600±15 nm), a negative surface potential (-36.70 mV), high drug loading (131.590 mg/g OMC), and excellent photothermal properties. The PEG-LIP@OMC/DOX can deliver loaded DOX to human MCF-7 breast cancer cells (MCF-7) and the cell toxicity viability shows that DOX unloaded PEG-LIP@OMC has no cytotoxicity, confirming the PEG-LIP@OMC itself has excellent biocompatibility. The NIR-triggered release studies demonstrate that this NIR-responsive drug delivery system enables on-demand drug release. Furthermore, cell viability results using human MCF-7 cells demonstrated that the combination of NIR-based hyperthermal therapy and triggered chemotherapy can provide higher therapeutic efficacy than respective monotherapies. With these excellent features, we believe that this phospholipid coating based multifunctional delivery system strategy should promote the application of OMC in nanomedical applications.
1. [1]
  A. Vinu, T. Mori, K. Ariga, Sci. Technol. Adv. Mat. 7(2006) 753-771. doi: 10.1016/j.stam.2006.10.007
2. [2]
  N.D. Petkovich, A. Stein, Chem. Soc. Rev. 42(2013) 3721-3739. doi: 10.1039/C2CS35308C
3. [3]
  C.Y. Hong, X. Li, C.Y. Pan, J. Mater. Chem. 19(2009) 5155-5160. doi: 10.1039/b820534e
4. [4]
  Q. Gao, Y. Xu, D. Wu, et al., J. Phys. Chem. C 113(2009) 12753-12758. doi: 10.1021/jp9043978
5. [5]
  N.K. Mal, M. Fujiwara, Y. Tanaka, Nature 421(2003) 350-353. doi: 10.1038/nature01362
6. [6]
  N.K. Mal, M. Fujiwara, Y. Tanaka, et al., Chem. Mater. 15(2003) 3385-3394. doi: 10.1021/cm0343296
7. [7]
  Y.Z. You, K.K. Kalebaila, S.L. Brock, et al., Chem. Mater. 20(2008) 3354-3359. doi: 10.1021/cm703363w
8. [8]
  A. Schlossbauer, S. Warncke, P.M.E. Gramlich, et al., Angew. Chem. Int. Ed. 49(2010) 4734-4737. doi: 10.1002/anie.201000827
9. [9]
  H. Kim, S. Kim, C. Park, et al., Adv. Mater. 22(2010) 4280-4283. doi: 10.1002/adma.201001417
10. [10]
  Z. Luo, K. Cai, Y. Hu, et al., Angew. Chem. Int. Ed. 50(2011) 640-643. doi: 10.1002/anie.201005061
11. [11]
  C.L. Zhu, C.H. Lu, X.Y. Song, et al., Angew. Chem. Int. Ed. 130(2008) 2382-2383.
12. [12]
  K. Patel, S. Angelos, W.R. Dichtel, et al., J. Am. Chem. Soc. 130(2008) 2382-2383. doi: 10.1021/ja0772086
13. [13]
  F. Lu, J.F. Wang, L. Yang, et al., Chem. Commun. 51(2015) 9447-9450. doi: 10.1039/C5CC01725D
14. [14]
  G.X. Yang, R.C. Lv, F. He, et al., Nanoscale 7(2015) 13747-13758. doi: 10.1039/C5NR03085D
15. [15]
  X.J. Liu, F.F. Fu, K.B. Xu, et al., J. Mater. Chem. B 2(2014) 5358-5367. doi: 10.1039/c4tb00919c
16. [16]
  K.Y. Wang, H. Yao, Y. Meng, et al., Acta Biomater. 16(2015) 196-205. doi: 10.1016/j.actbio.2015.01.002
17. [17]
  Q.J. He, Y. Gao, L.X. Zhang, et al., Biomaterials 32(2011) 7711-7720. doi: 10.1016/j.biomaterials.2011.06.066
18. [18]
  Q.J. He, Z.W. Zhang, Y. Gao, et al., Small 5(2009) 2722-2729. doi: 10.1002/smll.200900923
19. [19]
  Y. Wang, K.Y. Wang, X.Y. Yan, et al., Adv. Healthc. Mater. 3(2014) 485-489. doi: 10.1002/adhm.201300324
20. [20]
  L. Chen, H. Zhang, J. Zheng, et al., Mater. Sci. Eng. C 84(2018) 21-31.
21. [21]
  S. Wang, C.Y. Li, Y. Meng, et al., ACS Biomater. Sci. Eng. 3(2017) 1702-1709. doi: 10.1021/acsbiomaterials.7b00326
22. [22]
  H.L. Li, J.M. Li, X.Y. He, et al., Chin. Chem. Lett. 30(2019) 1083-1088. doi: 10.1016/j.cclet.2019.01.003
23. [23]
  Y. Song, D. Li, J.L. He, et al., Chin. Chem. Lett. 30(2019) 2027-2031. doi: 10.1016/j.cclet.2019.04.052
24. [24]
  X. Duan, X. Yang, C.L. Dai, et al., Mater. Express 9(2019) 757-763. doi: 10.1166/mex.2019.1552
25. [25]
  J.K. Kundu, Y.J. Surh, Cancer Lett. 269(2008) 243-261. doi: 10.1016/j.canlet.2008.03.057
26. [26]
  M. Chen, S.N. Yang, X.X. He, et al., J. Mater. Chem. B 2(2014) 6064-6071.
27. [27]
  Q.Y. Li, C.G. Zhou, Z. Ji, et al., J. Mater. Chem. A 3(2015) 7241-7247. doi: 10.1039/C4TA06083K
28. [28]
  P. Selvam, B. Kuppan, Catal. Today 198(2012) 85-91. doi: 10.1016/j.cattod.2012.06.033
29. [29]
  S. Jun, S.H. Joo, R. Ryoo, et al., J. Am. Chem. Soc. 122(2000) 10712-10713.
30. [30]
  S.C. Qi, Y. Liu, A.Z. Peng, et al., Chem. Eng. J. 361(2019) 945-952.
31. [31]
  B. He, F.J. Liu, S.K. Yan, et al., J. Mater. Chem. A 5(2017) 18064-18070.
32. [32]
  J.J. Ma, P.J. Li, W.W. Wang, et al., ACS Nano 12(2018) 9022-9032.
1. [1]
  Shengyi Gong , Guoqiang Feng . Visible light-triggered NIR ratiometric fluorescent metal-free CO-releasing molecule for self-monitoring of CO delivery and effective cancer therapy. Chinese Chemical Letters, 2025, 36(7): 110409-. doi: 10.1016/j.cclet.2024.110409
2. [2]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
3. [3]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
4. [4]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
5. [5]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
6. [6]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
7. [7]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
8. [8]
  Haijun Shen , Yi Qiao , Chun Zhang , Yane Ma , Jialing Chen , Yingying Cao , Wenna Zheng . A matrix metalloproteinase-sensitive hydrogel combined with photothermal therapy for transdermal delivery of deferoxamine to accelerate diabetic pressure ulcer healing. Chinese Chemical Letters, 2024, 35(12): 110283-. doi: 10.1016/j.cclet.2024.110283
9. [9]
  Linjie Ju , Zhongxi Huang , Qian Shen , Chan Fu , Shuanghe Li , Wenjie Duan , Chenfeng Xu , Weizhen An , Zhiqiang Zhai , Jifu Wei , Changmin Yu , Guoren Zhou . Glutathione depletion based Pt(Ⅳ) hybrid mesoporous organosilica delivery system to conquer cisplatin chemoresistance: A “one stone three birds” strategy. Chinese Chemical Letters, 2024, 35(10): 109450-. doi: 10.1016/j.cclet.2023.109450
10. [10]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742
11. [11]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
12. [12]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
13. [13]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672
14. [14]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
15. [15]
  Li Fu , Ziye Su , Shuyang Wu , Yanfen Cheng , Chuan Hu , Jinming Zhang . Redox-responsive hyaluronic acid-celastrol prodrug micelles with glycyrrhetinic acid co-delivery for tumor combination therapy. Chinese Chemical Letters, 2025, 36(5): 110227-. doi: 10.1016/j.cclet.2024.110227
16. [16]
  Lulu Cao , Yikun Li , Dongxiang Zhang , Shuai Yue , Rong Shang , Xin-Dong Jiang , Jianjun Du . Engineering aggregates of julolidine-substituted aza-BODIPY nanoparticles for NIR-II photothermal therapy. Chinese Chemical Letters, 2024, 35(12): 109735-. doi: 10.1016/j.cclet.2024.109735
17. [17]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
18. [18]
  Bing Xie , Qi Jiang , Fang Zhu , Yaoyao Lai , Yueming Zhao , Wei He , Pei Yang . Transdermal delivery of amphotericin B using deep eutectic solvents for antifungal therapy. Chinese Chemical Letters, 2025, 36(5): 110508-. doi: 10.1016/j.cclet.2024.110508
19. [19]
  Huijuan Zhang , Chenglin Liang , Xinyi Ding , Meng Zhang , Siyu Lu , Lin Hou . Manganese-based nano-delivery system for sensitized anti-tumor immunotherapy via combined autophagy inhibition. Chinese Chemical Letters, 2025, 36(7): 110525-. doi: 10.1016/j.cclet.2024.110525
20. [20]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967

Get Citation

PDF

XML

Metrics

PDF Downloads(14)
Abstract views(1216)
HTML views(143)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142