Citation: Zhou Hui, Li Shanshan, Zeng Xiaodong, Zhang Mengxian, Tang Lin, Li Qianqian, Chen Deliang, Meng Xianli, Hong Xuechuan. Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging[J]. Chinese Chemical Letters, ;2020, 31(6): 1382-1386. doi: 10.1016/j.cclet.2020.04.030 shu

Tumor-homing peptide-based NIR-II probes for targeted spontaneous breast tumor imaging

Zhou Hui ^a,b,1 ,
Li Shanshan ^b,1 ,
Zeng Xiaodong ^b ,
Zhang Mengxian ^b ,
Tang Lin ^b ,
Li Qianqian ^b ,
Chen Deliang ^d,*, ,
Meng Xianli ^a,**, ,
Hong Xuechuan ^a,b,c,**,

a.
Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
b.
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery(MOE), Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Shenzhen Institute of Wuhan University, Shenzhen 518057, China
c.
College of Science, Innovation Center for Traditional Tibetan Medicine Modernization and Quality Control, Medical College, Tibet University, Lasa 850000, China
d.
Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou 341000, China

^**

dechen@gnnu.cn

xlm999@cdutcm.edu.cn

xhy78@whu.edu.cn

Received Date: 4 March 2020
Revised Date: 8 April 2020
Accepted Date: 16 April 2020
Available Online: 19 April 2020

Figures(5)

Fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) is a promising modality for real-time imaging of cancer and image-guided surgery with superior in vivo optical properties. So far, very few NIR-II fluorophores have been reported for in vivo biomedical imaging of chemically-induced spontaneous breast carcinoma. Herein, a NIR-II fluorescent probe CH1055-F3 with the nucleolin-targeted tumor-homing peptide F3 was demonstrated to preferentially accumulate in 4T1 tumors. More importantly, CH1055-F3 exhibited specific NIR-II signals with high spatial and temporal resolution, strong tumor uptake, and remarkable NIR-II image-guided surgery in dimethylbenzan-thracene (DMBA)-induced spontaneous breast tumor rats. This report presents the first tumor-homing peptide-based NIR-II probe to diagnose transplantable and spontaneous breast tumors by the active targeting.
- NIR-II imaging,
- F3 peptide,
- Image-guided surgery,
- Spontaneous breast carcinoma,
- NIR-II probes
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