Citation: Ziming Chen, Kuo Zhang, Jiaqi Fan, Yu Fan, Chao Yang, Wen Tian, Yuan Li, Wenliang Li, Jingping Zhang, Hao Wang, Lei Wang. In situ construction of ligand nano-network to integrin α_vβ₃ for angiogenesis inhibition[J]. Chinese Chemical Letters, ;2020, 31(12): 3107-3112. doi: 10.1016/j.cclet.2020.04.006 shu

In situ construction of ligand nano-network to integrin α_vβ₃ for angiogenesis inhibition

Ziming Chen ^{a, b} ,
Kuo Zhang ^b ,
Jiaqi Fan ^b ,
Yu Fan ^b ,
Chao Yang ^b ,
Wen Tian ^b ,
Yuan Li ^b ,
Wenliang Li ^a ,
Jingping Zhang ^a ,
Hao Wang ^b ,
Lei Wang ^{b, *,}

a.
Faculty of Chemistry, Northeast Normal University, Changchun 130024, China
b.
CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China

wanglei@nanoctr.cn

Received Date: 13 February 2020
Revised Date: 2 April 2020
Accepted Date: 4 April 2020
Available Online: 20 April 2020

Figures(5)

Angiogenesis occurs during the process of tumor growth, invasion and metastasis, and is essential for the survival of solid tumors. As an integrin significantly overexpressed in human tumor vascular endothelial cells, α_vβ₃ is a suitable targeting site for anti-angiogenesis of tumor. We designed and prepared a selfassembling peptide (SAP) with the ability to targeting α_vβ₃ and self-assembly. SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin α_vβ₃ on the surface of human umbilical vein endothelial cells (HUVECs). The SAP network stably anchored on HUVECs over 24 h, which consequently resulted in high-efficient inhibition of vascularization. In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%. In vivo anti-angiogenesis array based on chick chorioallantoic membrane (CAM) model exhibited that the SAP had an inhibition rate up to 63.1%. These results indicated the outstanding anti-angiogenic ability of SAP, potentially for tumor therapy.
- Self-assembly,
- Integrin α_vβ₃,
- Peptide,
- Anti-angiogenesis,
- Tumor
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition

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通讯作者: 陈斌, bchen63@163.com

In situ construction of ligand nano-network to integrin α_vβ₃ for angiogenesis inhibition