Citation: Yadong Feng, Zhengping Wu, Ting Chen, Qi Fu, Qihua You, Jinhai Shen, Xiuling Cui. Palladium-catalyzed oxidative homocoupling of 2-arylquinazolinones[J]. Chinese Chemical Letters, ;2020, 31(12): 3263-3266. doi: 10.1016/j.cclet.2020.03.080 shu

Palladium-catalyzed oxidative homocoupling of 2-arylquinazolinones

Yadong Feng ^{a, b, *,} ,
Zhengping Wu ^a ,
Ting Chen ^a ,
Qi Fu ^a ,
Qihua You ^a ,
Jinhai Shen ^a ,
Xiuling Cui ^{b, *,}

a.
College of Environment and Public Health, Xiamen Huaxia University, Xiamen 361024, China
b.
Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Fujian Molecular Medicine, Key Laboratory of Precision Medicine and Molecular Diagnosis of Fujian Universities, Key Laboratory of Xiamen Marine and Gene Drugs, School of Biomedical Sciences, Huaqiao University, Xiamen 361021, China

fengyd@hxxy.edu.cn

cuixl@hqu.edu.cn

Received Date: 8 March 2020
Revised Date: 20 March 2020
Accepted Date: 31 March 2020
Available Online: 15 April 2020

Figures(5)

Pd-catalyzed oxidative homocoupling of 2-arylquinazolinones was successfully developed for the direct construction of biaryls via C-H bond activation. New well-defined structure that possessed two quinazolinone units was obtained with high efficiency and atomic economy. The protocols offer an efficient approach to the synthetically useful and functionalized biaryls in good yields using quinazolinone as a directing group.
- 2-Arylquinazolinones,
- Homocoupling,
- Palladium-catalyzed,
- C-H bond activation
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