Citation: Shifang Wen, Kuo Zhang, Yuan Li, Jiaqi Fan, Ziming Chen, Jingping Zhang, Hao Wang, Lei Wang. A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis[J]. Chinese Chemical Letters, ;2020, 31(12): 3153-3157. doi: 10.1016/j.cclet.2020.03.077 shu

A self-assembling peptide targeting VEGF receptors to inhibit angiogenesis

Shifang Wen ^{a, b, 1} ,
Kuo Zhang ^{b, 1} ,
Yuan Li ^b ,
Jiaqi Fan ^b ,
Ziming Chen ^{a, b} ,
Jingping Zhang ^{a, *,} ,
Hao Wang ^b ,
Lei Wang ^{b, *,}

a.
Faculty of Chemistry, Northeast Normal University, Changchun 130024, China
b.
Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190, China

zhangjp162@nenu.edu.cn

wanglei@nanoctr.cn

Received Date: 28 February 2020
Revised Date: 30 March 2020
Accepted Date: 30 March 2020
Available Online: 23 April 2020

Figures(5)

Vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR) pathways are essential in tumor angiogenesis, growth and metastasis. Studies on anti-angiogenic therapy have been mostly focused on the blockage of VEGF-VEGFR pathways. We report an extracellularly transformable peptide-based nanomaterial to develop artificial extracellular matrix (ECM)-like networks for high-efficient blockage of natural VEGF-VEGFR interactions. The transformable peptide-based nanomaterial transforms from nanoparticles into nanofibers upon binding to VEGFR in solution. In addition, the transformable peptide-based nanomaterial forms ECM-like fibrous networks on VEGFR overexpressed cells, inhibiting the VEGF-VEGFR interactions and the subsequent angiogenesis. The tube formation is reduced by nearly 85.1% after treatment. This strategy shows excellent potential for anti-angiogenesis, and inhibition of tumor invasion and metastasis.
- Self-assembly,
- Peptide,
- VEGF,
- Angiogenesis,
- Biomimetic
1. [1]
  J. Folkman, M. Bach, J.W. Rowe, et al., N. Engl. J. Med. 285(1971) 1182-1186. doi: 10.1056/NEJM197111182852108
2. [2]
  J. Folkman, Nat. Rev. Drug. Discov. 6(2007) 273-286. doi: 10.1038/nrd2115
3. [3]
  D.M. Chase, D.J. Chaplin, B.J. Monk, Gynecol. Oncol. 145(2017) 393-406. doi: 10.1016/j.ygyno.2017.01.031
4. [4]
  N. Ferrara, A.P. Adamis, Nat. Rev. Drug. Discov. 15(2016) 385-403. doi: 10.1038/nrd.2015.17
5. [5]
  A.R. Reynolds, I.R. Hart, A.R. Watson, et al., Nat. Med. 15(2009) 392-400. doi: 10.1038/nm.1941
6. [6]
  A.S. Chung, N. Ferrara, Annu. Rev. Cell Dev. Biol. 27(2011) 563-584. doi: 10.1146/annurev-cellbio-092910-154002
7. [7]
  A.S. Chung, J. Lee, N. Ferrara, Nat. Rev. Cancer 10(2010) 505-514. doi: 10.1038/nrc2868
8. [8]
  D. Fukumura, J. Kloepper, Z. Amoozgar, et al., Nat. Rev. Clin. Oncol. 15(2018) 325-340. doi: 10.1038/nrclinonc.2018.29
9. [9]
  R.S. Apte, D.S. Chen, N. Ferrara, Cell 176(2019) 1248-1264. doi: 10.1016/j.cell.2019.01.021
10. [10]
  R.K. Jain, Cancer Cell 26(2014) 605-622. doi: 10.1158/1538-8514.TUMANG15-IA03
11. [11]
  V.L. Heath, R. Bicknell, Nat. Rev. Clin. Oncol. 6(2009) 395-404. doi: 10.1038/nrclinonc.2009.52
12. [12]
  K. Zhang, Y.J. Gao, P.P. Yang, et al., Adv. Healthc. Mater. 7(2018) 1800344. doi: 10.1002/adhm.201800344
13. [13]
  R.J. Giordanoa, M. Cardó-Vilaa, A. Salameha, et al., PNAS 11(2010) 5112-5117. doi: 10.1073/pnas.0915141107
14. [14]
  H. Koide, K. Yoshimatsu, Y. Hoshino, et al., Nat. Chem. 9(2017) 715-722. doi: 10.1038/nchem.2749
15. [15]
  B. Yu, D. Hwang, H. Jeon, Angew. Chem. Int. Ed. 58(2018) 2005-2010.
16. [16]
  G.B. Qi, Y.J. Gao, L. Wang, H. Wang, Adv. Mater. 30(2018) 1703444.
17. [17]
  Q. Luo, Y.X. Lin, P.P. Yang, et al., Nat. Commun. 9(2018) 1802. doi: 10.1038/s41467-018-04255-z
18. [18]
  P.P. Yang, C. Yang, K. Zhang, L. Wang, H. Wang, Chin. Chem. Lett. 29(2018) 1811-1814.
19. [19]
  P.P. He, X.D. Li, L. Wang, H. Wang, Acc. Chem. Res. 52(2019) 367-378.
20. [20]
  X.X. Hu, P.P. He, G.B. Qi, et al., ACS Nano 11(2017) 4086-4096.
21. [21]
  L. Wang, W. Li, J. Lu, et al., J. Phys. Chem. C 117(2013) 26811-26820. doi: 10.1021/jp409557g
22. [22]
  J.S. Michaloski, A.R. Redondo, L.S. Magalhães, Sci. Adv. 2(2016) e1600611. doi: 10.1126/sciadv.1600611
23. [23]
  A.P. Xu, P.P. Yang, C. Yang, et al., Nanoscale 8(2016) 14078-14083.
24. [24]
  E.T. Kaiser, H. Wang, V. Stepanenko, et al., Angew. Chem. Int. Ed. 46(2007) 5541-5544. doi: 10.1002/ange.200701139
25. [25]
  V.Castelletto, I.W.Hamley, P.J.F.Harris, etal., J.Phys.Chem.B113(2009)9978-9987. doi: 10.1021/jp902860a
26. [26]
  L. Niu, L. Liu, M. Xu, et al., Chem. Commun. 50(2014) 8923-8926.
27. [27]
  J.X. Ding, X.R. Feng, Z.Y. Jiang, et al., Biomacromolecules 20(2019) 4258-4271.
28. [28]
  J.X. Ding, J.J. Chen, L.Q. Gao, et al., Nano Today 29(2019) 100800.
29. [29]
  K. Zhang, P.P. Yang, J.P. Zhang, L. Wang, H. Wang, Chin. Chem. Lett. 28(2017) 1808-1816.
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