Citation: Kaijie Wang, Dazhou Xi, Chuantao Liu, Yahui Chen, Hao Gu, Long Jiang, Xiaoqiang Chen, Fang Wang. A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications[J]. Chinese Chemical Letters, ;2020, 31(11): 2955-2959. doi: 10.1016/j.cclet.2020.03.064 shu

A ratiometric benzothiazole-based fluorescence probe for selectively recognizing HClO and its practical applications

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing 211816, China

fangwang@njtech.edu.cn

Received Date: 27 February 2020
Accepted Date: 24 March 2020
Available Online: 29 May 2020

Figures(6)

A ratiometric probe (HBT-HBZ) bearing 2-hydrazino benzothiazole and 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde for sensing hypochlorous acid (HClO) with high selectivity and sensitivity is reported in this article. The fluorescence intensity ratios (I_{470 nm}/I_{572 nm}) of the probe with different concentrations of analyte showed excellent selectivity and a linear response to minor changes in HClO. The detection limit of 24 nmol/L suggests that the sensor is very sensitive to HClO. According to the series of performed experiments, HBT-HBZ has practical applications, such as the detection of HClO residues in tap water, which has been rarely reported. In addition, confocal laser microscopy experiments confirmed that HBT-HBZ can selectively recognize HClO in HeLa cells. A ratiometric probe (HBT-HBZ) for sensing HClO with high selectivity and sensitivity is reported in this article. The probe exhibited high selectivity for HClO among other ROS, RNS and anions. In addition, HBTHBZ has some practical applications such as the analysis of the HClO content in tap water. Furthermore, confocal fluorescence microscopy imaging showed that HBT-HBZ can be applied for detecting HClO in living cells.
- HClO,
- Benzothiazole,
- Fluorescence probe,
- Tap water,
- Bioimaging
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