Citation: Li Yingxue, Zeng Bo, Yang Yujie, Liang Huageng, Yang Yanbing, Yuan Quan. Design of high stability thin-film transistor biosensor for the diagnosis of bladder cancer[J]. Chinese Chemical Letters, ;2020, 31(6): 1387-1391. doi: 10.1016/j.cclet.2020.03.043 shu

Design of high stability thin-film transistor biosensor for the diagnosis of bladder cancer

Li Yingxue ^a,1 ,
Zeng Bo ^a,1 ,
Yang Yujie ^a ,
Liang Huageng ^c,**, ,
Yang Yanbing ^a,b,d,*, ,
Yuan Quan ^a,b,*,

a.
Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China
b.
Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
c.
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
d.
Key Laboratory for Micro-/Nano-Optoelectronic Devices of Ministry of Education, School of Physics and Electronics, Hunan University, Changsha 410082, China

^**

leonard19800318@hust.edu.cn

yangyanbing@whu.edu.cn

yuanquan@whu.edu.cn

Received Date: 14 January 2020
Revised Date: 9 March 2020
Accepted Date: 15 March 2020
Available Online: 18 March 2020

Figures(5)

Bladder cancer is the most common malignant tumor in the urinary system, with high morbidity, mortality and recurrence after surgery. However, current bladder cancer urine diagnosis methods are limited by the low accuracy and specificity due to the low abundance of bladder cancer biomarkers in the urine with complex biological environments. Herein, we present a high stability indium gallium zinc oxide field effect transistor (IGZO-FET) biosensor for efficient identification of bladder cancer biomarkers from human urine samples. The recognition molecular functionalized IGZO-FET biosensor exhibits stable electronic and sensing performance due to the large-area fabrication of IGZO thin-film FET. Owing to the excellent electrical performance of IGZO-FET, the IGZO-FET biosensor exhibits high sensitivity and extremely low detection limit (2.7 amol/L) towards bladder cancer biomarkers. The IGZO-FET biosensor is also able to directly detect bladder tumor biomarker in human urine with high sensitivity and specificity, and could differentiate bladder cancer patients' urine samples from healthy donors effectively. These results indicate that our designed high-performance biosensor shows great potential in the application of portable digital bladder cancer diagnosis devices.
- IGZO,
- Field-effect transistors,
- NMP22,
- Bladder cancer,
- Urine detection
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