Citation: Du Jintong, Guo Jing, Kang Dongwei, Li Zhihong, Wang Guan, Wu Jianbing, Zhang Zhen, Fang Hao, Hou Xuben, Huang Zhangjian, Li Guobo, Lu Xiaoyun, Liu Xinyong, Ouyang Liang, Rao Li, Zhan Peng, Zhang Xiaojin, Zhang Yihua. New techniques and strategies in drug discovery[J]. Chinese Chemical Letters, ;2020, 31(7): 1695-1708. doi: 10.1016/j.cclet.2020.03.028 shu

New techniques and strategies in drug discovery

Du Jintong ^a,1 ,
Guo Jing ^b,1 ,
Kang Dongwei ^c,1 ,
Li Zhihong ^d,1 ,
Wang Guan ^e,1 ,
Wu Jianbing ^f,1 ,
Zhang Zhen ^b ,
Fang Hao ^c,*, ,
Hou Xuben ^c,*, ,
Huang Zhangjian ^f, ,
Li Guobo ^g,*, ,
Lu Xiaoyun ^b,*, ,
Liu Xinyong ^c,*, ,
Ouyang Liang ^e,*, ,
Rao Li ^h,*, ,
Zhan Peng ^c,*, ,
Zhang Xiaojin ^d,*, ,
Zhang Yihua ^f,*,

a.
Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan 250117, China
b.
School of Pharmacy, Ji'nan University, Guangzhou 510632, China
c.
Department of Medicinal Chemistry, Key Laboratory of Chemical Biology(Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Ji'nan 250012, China
d.
Department of Chemistry, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 211198, China
e.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China
f.
State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China
g.
Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
h.
Key Laboratory of Pesticide & Chemical Biology(CCNU), Ministry of Education, Department of Chemistry, Central China Normal University, Wuhan 430079, China

haofangcn@sdu.edu.cn

hxb@sdu.edu.cn

zhangjianhuang@cpu.edu.cn

liguobo@scu.edu.cn

luxy2016@jnu.edu.cn

xinyongl@sdu.edu.cn

ouyangliang@scu.edu.cn

raoli@mail.ccnu.edu.cn

zhanpeng1982@sdu.edu.cn

zyhtgd@163.com

Received Date: 27 November 2019
Revised Date: 7 March 2020
Accepted Date: 8 March 2020
Available Online: 9 March 2020

Figures(15)

Great success has been witnessed in last decades, some new techniques and strategies have been widely used in drug discovery. In this roadmap, several representative techniques and strategies are highlighted to show recent advances in this filed. (A) A DOX protocol has been developed for accurate protein-ligand binding structure prediction, in which first principle method was used to rank the binding poses. Validation against crystal structures have found that DOX prediction achieved an impressive success rate of 99%, indicating significant improvement over molecular docking method. (B) Virtual target profiling is a compound-centric strategy enabling a parallel implementation of interrogating compounds against various targets in a single screen, which has been used in hit/lead identification, drug repositioning, and mechanism-of-action studies. Current and emerging methods for virtual target profiling are briefly summarized herein. (C) Research on targeted autophagy to treat diseases has received encouraging progress. However, due to the complexity of autophagy and disease, experimental and in silico methods should be performed synergistically for the entire process. This part focuses on in silico methods in autophagy research to promote their use in medicinal research. (D) Histone deacetylases (HDACs) play important roles in various biological functions through the deacetylation of lysine residues. Recent studies demonstrated that HDACs, which possess low deacetylase activities, exhibited more efficient defatty-acylase activities. Here, we review the defatty-acylase activity of HDACs and describe examples for the design of isoform selective HDAC inhibitor. (E) The FDA approval of three kinase allosteric inhibitors and some others entering clinical study has spurred considerable interests in this targeted drug discovery area. (F) Recent advances are reviewed in structure-based design of novel antiviral agents to combat drug resistance. (G) Since nitric oxide (NO) exerts anticancer activity depending on its concentration, optimal levels of NO in cancer cells is desirable. In this minireview, we briefly describe recent advances in the research of NO-based anticancer agents by our group and present some opinions on the future development of these agents. (H) The field of photoactivation strategies have been extensively developed for controlling chemical and biological processes with light. This review will summarize and provide insight into recent research advances in the understanding of photoactivatable molecules including photoactivatable caged prodrugs and photoswitchable molecules.
- Protein-ligand binding structure,
- Target profiling,
- In silico autophagy method,
- Defatty-acylase,
- Allosteric kinase inhibitor,
- Drug resistance,
- Nitric oxide donor,
- Photoactivation strategies
1. [1]
  D. Plewczynski, M. Lazniewski, R. Augustyniak, K. Ginalski, J. Comput. Chem. 32 (2011) 742-755. doi: 10.1002/jcc.21643
2. [2]
  I.D. Kuntz, J.M. Blaney, S.J. Oatley, R. Langridge, T.E. Ferrin, J. Mol. Bio. 161 (1982) 269-288. doi: 10.1016/0022-2836(82)90153-X
3. [3]
  Z. Zsoldos, D. Reid, A. Simon, S.B. Sadjad, A.P. Johnson, J. Mol. Graph. Model 26 (2007) 198-212. doi: 10.1016/j.jmgm.2006.06.002
4. [4]
  M.K. Rarey, B. Kramer, T. Lengauer, G. Klebe, J. Mol. Bio. 261 (1996) 470-489. doi: 10.1006/jmbi.1996.0477
5. [5]
  R.A. Friesner, J.L. Banks, R.B. Murphy, et al., J. Med. Chem. 47 (2004) 1739-1749. doi: 10.1021/jm0306430
6. [6]
  G.W. Jones, P. Willete, R.C. Glen, A.R. Leach, R. Taylor, J. Mol. Bio. 267 (1997) 727-748. doi: 10.1006/jmbi.1996.0897
7. [7]
  C. Venkatachalam, X. Jiang, T. Oldfield, M. Waldman, J. Mol. Graphics Modell. 21 (2003) 289-307. doi: 10.1016/S1093-3263(02)00164-X
8. [8]
  A.N. Jain, J. Med. Chem. 46 (2003) 499-511. doi: 10.1021/jm020406h
9. [9]
  G.M. Morris, R. Huey, W. Lindstrom, et al., J. Comput. Chem. 30 (2009) 2785-2791. doi: 10.1002/jcc.21256
10. [10]
  L. Rao, B. Chi, Y. Ren, et al., J. Comput. Chem. 37 (2016) 336-344. doi: 10.1002/jcc.24217
11. [11]
  L. Wei, B. Chi, Y. Ren, et al., J. Chem. Theory Comput. 15 (2019) 4264-4279. doi: 10.1021/acs.jctc.8b01150
12. [12]
  W. Guo, A. Wu, I.Y. Zhang, X. Xu, J. Comput. Chem. 33 (2012) 2142-2160. doi: 10.1002/jcc.23051
13. [13]
  M. Zheng, X. Liu, Y. Xu, et al., Trends Pharmacol. Sci. 34 (2013) 549-559. doi: 10.1016/j.tips.2013.08.004
14. [14]
  S.Y. Yang, Drug Discov. Today 15 (2010) 444-450. doi: 10.1016/j.drudis.2010.03.013
15. [15]
  X. Liu, H. Jiang, H. Li, J. Chem. Inf. Model. 51 (2011) 2372-2385. doi: 10.1021/ci200060s
16. [16]
  W. Lu, X. Liu, X. Cao, et al., J. Med. Chem. 54 (2011) 3564-3574. doi: 10.1021/jm200139j
17. [17]
  G.B. Li, S. Ji, L.L. Yang, et al., Eur. J. Med. Chem. 93 (2015) 523-538. doi: 10.1016/j.ejmech.2015.02.019
18. [18]
  G.B. Li, M.I. Abboud, J. Brem, et al., Chem. Sci. 8 (2017) 928-937. doi: 10.1039/C6SC04524C
19. [19]
  K.A. O'Connor, B.L. Roth, Nat. Rev. Drug Discov. 4 (2005) 1005-1014. doi: 10.1038/nrd1900
20. [20]
  A. Corbett, J. Pickett, A. Burns, et al., Nat. Rev. Drug Discov.11 (2012) 833-846. doi: 10.1038/nrd3869
21. [21]
  Y.Z. Chen, D.G. Zhi, Proteins 43 (2001) 217-226. doi: 10.1002/1097-0134(20010501)43:2<217::AID-PROT1032>3.0.CO;2-G
22. [22]
  H. Li, Z. Gao, L. Kang, et al., Nucleic Acids Res. 34 (2006) W219-W224. doi: 10.1093/nar/gkl114
23. [23]
  J.C. Wang, P.Y. Chu, C.M. Chen, J.H. Lin, Nucleic Acids Res. 40 (2012) W393-W399. doi: 10.1093/nar/gks496
24. [24]
  K.T. Schomburg, S. Bietz, H. Briem, et al., J. Chem. Inf. Model. 54 (2014) 1676-1686. doi: 10.1021/ci500130e
25. [25]
  X. Liu, S. Ouyang, B. Yu, et al., Nucleic Acids Res. 38 (2010) W609-W614. doi: 10.1093/nar/gkq300
26. [26]
  X. Wang, Y. Shen, S. Wang, et al., Nucleic Acids Res. 45 (2017) W356-W360. doi: 10.1093/nar/gkx374
27. [27]
  A. Brakoulias, R.M. Jackson, Proteins 56 (2004) 250-260. doi: 10.1002/prot.20123
28. [28]
  C. Schalon, J.S. Surgand, E. Kellenberger, D. Rognan, Proteins 71 (2008) 1755-1778. doi: 10.1002/prot.21858
29. [29]
  Z. Chen, X. Zhang, C. Peng, et al., J. Chem. Inf. Model. 59 (2019) 3353-3358. doi: 10.1021/acs.jcim.9b00332
30. [30]
  M.J. Keiser, B.L. Roth, B.N. Armbruster, et al., Nat. Biotechnol. 25 (2007) 197-206. doi: 10.1038/nbt1284
31. [31]
  M.J. Keiser, V. Setola, J.J. Irwin, et al., Nature 462 (2009) 175-181. doi: 10.1038/nature08506
32. [32]
  J. Gong, C. Cai, X. Liu, et al., Bioinformatics 29 (2013) 1827-1829. doi: 10.1093/bioinformatics/btt270
33. [33]
  S.L. Kinnings, R.M. Jackson, J. Chem. Inf. Model. 51 (2011) 624-634. doi: 10.1021/ci1003174
34. [34]
  G.B. Li, L.L. Yang, Y. Xu, et al., J. Mol. Graph. Model. 44 (2013) 278-285. doi: 10.1016/j.jmgm.2013.07.005
35. [35]
  G.B. Li, Z.J. Yu, S. Liu, et al., J. Chem. Inf. Model. 57 (2017) 1640-1651. doi: 10.1021/acs.jcim.7b00225
36. [36]
  G.B. Li, L.L. Yang, W.J. Wang, et al., J. Chem. Inf. Model. 53 (2013) 592-600. doi: 10.1021/ci300493w
37. [37]
  X. Zhou, M. Wu, Y. Xie, et al., Front. Pharmacol. 9 (2018) 1238. doi: 10.3389/fphar.2018.01238
38. [38]
  Z. Li, X. Li, X. Liu, et al., Bioinformatics 35 (2019) 5354-5356. doi: 10.1093/bioinformatics/btz519
39. [39]
  D.J. Klionsky, S.D. Emr, Science 290 (2000) 1717-1721. doi: 10.1126/science.290.5497.1717
40. [40]
  R. Khandia, M. Dadar, A. Munjal, et al., Cells 8 (2019) E674. doi: 10.3390/cells8070674
41. [41]
  N. Wang, L. Wang, X.Q. Xie, J. Chem. Inf. Model. 57 (2017) 2686-2698. doi: 10.1021/acs.jcim.7b00277
42. [42]
  T. Xie, L. Zhang, S. Zhang, et al., Oncotarget 7 (2016) 10015-10022. doi: 10.18632/oncotarget.7015
43. [43]
  A.C. Jacomin, S. Samavedam, V. Promponas, I.P. Nezis, Autophagy 12 (2016) 1945-1953. doi: 10.1080/15548627.2016.1207016
44. [44]
  Y. Deng, L. Zhu, H. Cai, et al., Cell. Proliferat. 51 (2018)e12403. doi: 10.1111/cpr.12403
45. [45]
  N.N. Wang, J. Dong, L. Zhang, et al., J. Cheminform. 10 (2018) 34. doi: 10.1186/s13321-018-0289-4
46. [46]
  R. Nanduri, R. Kalra, E. Bhagyaraj, et al., Autophagy 15 (2019) 1280-1295. doi: 10.1080/15548627.2019.1571717
47. [47]
  C.S. Börlin, V. Lang, A. Hamacher-Brady, N.R. Brady, Cell Commun. Signal 12 (2014) 56.
48. [48]
  I. Tavassoly, J. Parmar, A.N. Shajahan-Haq, et al., CPT Pharmacometrics Syst. Pharmacol. 4 (2015) 263-272. doi: 10.1002/psp4.29
49. [49]
  J. Scheidel, L. Amstein, J. Ackermann, et al., PLoS Comput. Biol. 12 (2016) e1005200. doi: 10.1371/journal.pcbi.1005200
50. [50]
  E. Aslan, N. Küçükoglu, M. Arslanyolu, Peer J 5 (2017) e2878. doi: 10.7717/peerj.2878
51. [51]
  F.M. Awan, A. Obaid, A. Ikram, H.A. Janjua, Int. J. Mol. Sci. 18 (2017) E139. doi: 10.3390/ijms18010139
52. [52]
  T.E. Hoffman, K.J. Barnett, L. Wallis, W.H. Hanneman, Aging Cell 16 (2017) 1244-1255. doi: 10.1111/acel.12644
53. [53]
  J. Zhou, D. Hang, Y. Jiang, et al., Gene 627 (2017) 549-555. doi: 10.1016/j.gene.2017.06.053
54. [54]
  J.M. Heo, A. Ordureau, S. Swarup, et al., Sci. Adv. 4 (2018) eaav0443. doi: 10.1126/sciadv.aav0443
55. [55]
  C. Xuan, Y. Gao, M. Jin, et al., IUBMB Life 71 (2019) 827-834. doi: 10.1002/iub.1999
56. [56]
  J. Pei, N. Yin, X. Ma, L. Lai, J. Am. Chem. Soc. 136 (2014) 11556-11565. doi: 10.1021/ja504810z
57. [57]
  S. Lu, M. Ji, D. Ni, J. Zhang, Drug Discov. Today 23 (2018) 359-365. doi: 10.1016/j.drudis.2017.10.001
58. [58]
  X. Yang, Y. Wang, R. Byrne, et al., Chem. Rev. 119 (2019) 10520-10594. doi: 10.1021/acs.chemrev.8b00728
59. [59]
  X.J. Yang, E. Seto, Oncogene 26 (2007) 5310-5318. doi: 10.1038/sj.onc.1210599
60. [60]
  G.P. Delcuve, D.H. Khan, J.R. Davie, Clin. Epigenetics 4 (2012) 5. doi: 10.1186/1868-7083-4-5
61. [61]
  P. Bheda, H. Jing, C. Wolberger, et al., Annu. Rev. Biochem. 85 (2016) 405-429. doi: 10.1146/annurev-biochem-060815-014537
62. [62]
  M.D. Resh, Prog. Lipid Res. 63 (2016) 120-131. doi: 10.1016/j.plipres.2016.05.002
63. [63]
  H. Jiang, X.Y. Zhang, H.N. Lin, Sci. Rep. 6 (2016) 24371.
64. [64]
  T. Peng, E. Thinon, H.C. Hang, Curr. Opin. Chem. Biol. 30 (2016) 77-86. doi: 10.1016/j.cbpa.2015.11.008
65. [65]
  J.L. Feldman, J. Baeza, J.M. Denu, J. Biol. Chem. 288 (2013) 31350-31356. doi: 10.1074/jbc.C113.511261
66. [66]
  J.L. Feldman, K.E. Dittenhafer-Reed, N. Kudo, et al., Biochemistry 54 (2015) 3037-3050. doi: 10.1021/acs.biochem.5b00150
67. [67]
  A.S. Madsen, C. Andersen, M. Daoud, et al., J. Biol. Chem. 291 (2016) 7128-7141. doi: 10.1074/jbc.M115.668699
68. [68]
  X.Y. Zhang, S. Khan, H. Jiang, et al., Nat. Chem. Biol. 12 (2016) 614-620. doi: 10.1038/nchembio.2106
69. [69]
  H. Jiang, S. Khan, Y. Wang, et al., Nature 496 (2013) 110-113. doi: 10.1038/nature12038
70. [70]
  Z. Tong, Y. Wang, X.Y. Zhang, et al., ACS Chem. Biol. 11 (2016) 742-747. doi: 10.1021/acschembio.5b01084
71. [71]
  Z. Tong, M. Wang, Y. Wang, et al., ACS Chem. Biol. 12 (2017) 300-310. doi: 10.1021/acschembio.6b00954
72. [72]
  P. Aramsangtienchai, N.A. Spiegelman, B. He, et al., ACS Chem. Biol. 11 (2016) 2685-2692. doi: 10.1021/acschembio.6b00396
73. [73]
  C. Moreno-Yruela, I. Galleano, A.S. Madsen, et al., Cell Chem. Biol. 25 (2018) 849-856. doi: 10.1016/j.chembiol.2018.04.007
74. [74]
  M.K. Wambua, D.A. Nalawansha, A.T. Negmeldin, et al., J. Med. Chem. 57 (2014) 642-650. doi: 10.1021/jm401837e
75. [75]
  D.F. Wang, O. Wiest, P. Helquist, et al., J. Med. Chem. 47 (2004) 3409-3417. doi: 10.1021/jm0498497
76. [76]
  Z. Kutil, Z. Novakova, M. Meleshin, et al., ACS Chem. Biol. 13 (2018) 685-693. doi: 10.1021/acschembio.7b00942
77. [77]
  L.L. Yang, X.B. Ma, C. Yuan, et al., Eur. J. Med. Chem. 134 (2017) 230-241. doi: 10.1016/j.ejmech.2017.04.010
78. [78]
  L.L. Yang, H.L. Wang, L. Zhong, et al., Eur. J. Med. Chem. 155 (2018) 806-823. doi: 10.1016/j.ejmech.2018.06.041
79. [79]
  B.C. Smith, J.M. Denu, Biochemistry 46 (2007) 14478-14486. doi: 10.1021/bi7013294
80. [80]
  H. Jing, J. Hu, B. He, et al., Cancer Cell 29 (2016) 767-768. doi: 10.1016/j.ccell.2016.04.005
81. [81]
  N.A. Spiegelman, J.Y. Hong, J. Hu, et al., ChemMedChem 14 (2019) 744-748. doi: 10.1002/cmdc.201800715
82. [82]
  A.S. Farooqi, J.Y. Hong, J. Cao, et al., J. Med. Chem. 62 (2019) 4131-4141. doi: 10.1021/acs.jmedchem.9b00191
83. [83]
  L. Whitehead, M.R. Dobler, B. Radetich, et al., Bioorg. Med. Chem. 19 (2011) 4626-4634. doi: 10.1016/j.bmc.2011.06.030
84. [84]
  B.E.L. Lauffer, R. Mintzer, R.N. Fong, et al., J. Biol. Chem. 288 (2013) 26926-26943. doi: 10.1074/jbc.M113.490706
85. [85]
  S.I. Son, J. Cao, C.L. Zhu, et al., ACS Chem. Biol. 14 (2019) 1393-1397. doi: 10.1021/acschembio.9b00292
86. [86]
  R. Roskoski Jr., Pharmacol. Res. 144 (2019) 19-50. doi: 10.1016/j.phrs.2019.03.006
87. [87]
  P. Wu, M.H. Clausen, T.E. Nielsen, Pharmacol. Therap. 156 (2015) 59-68. doi: 10.1016/j.pharmthera.2015.10.002
88. [88]
  S.W. Cowan-Jacob, W. Jahnke, S. Knapp, Future Med. Chem. 6 (2014) 541-561. doi: 10.4155/fmc.13.216
89. [89]
  H. Abe, S. Kikuchi, K. Hayakawa, et al., ACS Med. Chem. Lett. 2 (2011) 320-324. doi: 10.1021/ml200004g
90. [90]
  K.D. Rice, N. Aay, N.K. Anand, et al., ACS Med. Chem. Lett. 3 (2012) 416-421. doi: 10.1021/ml300049d
91. [91]
  A.A.N. Rose, Drugs Today (Barc) 55 (2019) 247-264. doi: 10.1358/dot.2019.55.4.2958476
92. [92]
  C. Robert, B. Karaszewska, J. Schachter, et al., N. Engl. J. Med. 372 (2015) 30-39. doi: 10.1056/NEJMoa1412690
93. [93]
  H. Hirai, H. Sootome, Y. Nakatsuru, et al., Mol. Cancer Therap. 9 (2010) 1956-1967. doi: 10.1158/1535-7163.MCT-09-1012
94. [94]
  T.A. Yap, L. Yan, A. Patnaik, et al., Clin. Cancer Res. 20 (2014) 5672-5685. doi: 10.1158/1078-0432.CCR-14-0868
95. [95]
  J.M. Lapierre, S. Eathiraj, D. Vensel, et al., J. Med. Chem. 59 (2016) 6455-6469. doi: 10.1021/acs.jmedchem.6b00619
96. [96]
  A.A. Wylie, J. Schoepfer, W. Jahnke, et al., Nature 543 (2017) 733-737. doi: 10.1038/nature21702
97. [97]
  J. Schoepfer, W. Jahnke, G. Berellini, et al., J. Med. Chem. 61 (2018) 8120-8135. doi: 10.1021/acs.jmedchem.8b01040
98. [98]
  C. Yueh, J. Rettenmaier, B. Xia, et al., J. Med. Chem. 62 (2019) 6512-6524. doi: 10.1021/acs.jmedchem.9b00089
99. [99]
  E. de Clercq, Med. Res. Rev. 33 (2013) 1249-1277. doi: 10.1002/med.21281
100. [100]
  P. Zhan, C. Pannecouque, E. de Clercq, X. Liu, J. Med. Chem. 59 (2016) 2849-2878. doi: 10.1021/acs.jmedchem.5b00497
101. [101]
  X. Zuo, Z. Huo, D. Kang, et al., Expert Opin. Ther. Pat. 28 (2018) 299-316. doi: 10.1080/13543776.2018.1438410
102. [102]
  P. Zhan, X. Chen, D. Li, et al., Med. Res. Rev. 33(Suppl 1) (2013) E1-E72.
103. [103]
  X. Jiang, J. Yu, Z. Zhou, et al., Med. Res. Rev. 39 (2019) 2194-2238. doi: 10.1002/med.21581
104. [104]
  B. Huang, W. Chen, T. Zhao, et al., J. Med. Chem. 62 (2019) 2083-2098. doi: 10.1021/acs.jmedchem.8b01729
105. [105]
  D. Kang, H. Zhang, Z. Wang, et al., J. Med. Chem. 62 (2019) 1484-1501. doi: 10.1021/acs.jmedchem.8b01656
106. [106]
  D. Kang, Z. Fang, B. Huang, et al., J. Med. Chem. 60 (2017) 4424-4443. doi: 10.1021/acs.jmedchem.7b00332
107. [107]
  D. Kang, Z. Fang, Z. Li, et al., J. Med. Chem. 59 (2016) 7991-8007. doi: 10.1021/acs.jmedchem.6b00738
108. [108]
  D.W. Kang, T. Zhao, Z. Wang, et al., Commun. Chem. 2 (2019) 74.
109. [109]
  Z. Huo, H. Zhang, D. Kang, et al., ACS Med. Chem. Lett. 9 (2018) 334-338. doi: 10.1021/acsmedchemlett.7b00524
110. [110]
  D. Kang, F.X. Ruiz, D. Feng, et al., J. Med. Chem. 63 (2020) 1298-1312. doi: 10.1021/acs.jmedchem.9b01769
111. [111]
  J. Zhang, V. Poongavanam, D. Kang, et al., J. Med. Chem. 61 (2018) 6379-6397. doi: 10.1021/acs.jmedchem.8b00929
112. [112]
  J. Zhang, N.A. Murugan, Y. Tian, et al., J. Med. Chem. 61 (2018) 9976-9999. doi: 10.1021/acs.jmedchem.8b01065
113. [113]
  Y. Yang, D. Kang, L.A. Nguyen, et al., eLife 7 (2018) e36340. doi: 10.7554/eLife.36340
114. [114]
  A.K. Ghosh, B.D. Chapsal, I.T. Weber, H. Mitsuya, Acc.Chem. Res. 41 (2008) 78-86. doi: 10.1021/ar7001232
115. [115]
  A.K. Ghosh, D.D. Anderson, I.T. Weber, H. Mitsuya, Angew. Chem. Int. Ed. 51 (2012) 1778-1802. doi: 10.1002/anie.201102762
116. [116]
  G. Wu, T. Zhao, D. Kang, et al., J. Med. Chem. 62 (2019) 9375-9414. doi: 10.1021/acs.jmedchem.9b00359
117. [117]
  I.W. Windsor, M.J. Palte, J.C. Lukesh 3rd., et al., J. Am. Chem. Soc. 140 (2018) 14015-14018. doi: 10.1021/jacs.8b07366
118. [118]
  A.H. Chan, W.G. Lee, K.A. Spasov, et al., Proc. Natl. Acad. Sci. U. S. A.114 (2017) 9725-9730. doi: 10.1073/pnas.1711463114
119. [119]
  M.D. Altman, A. Ali, G.S. Reddy, et al., J. Am. Chem. Soc.130 (2008) 6099-6113. doi: 10.1021/ja076558p
120. [120]
  L.N. Rusere, G.J. Lockbaum, S.K. Lee, et al., J. Med. Chem. 62 (2019) 8062-8079. doi: 10.1021/acs.jmedchem.9b00838
121. [121]
  X.Z. Zhao, S.J. Smith, D.P. Maskell, et al., J. Med. Chem. 60 (2017) 7315-7332. doi: 10.1021/acs.jmedchem.7b00596
122. [122]
  A.N. Matthew, J. Zephyr, C.J. Hill, et al., J. Med. Chem. 60 (2017) 5699-5716. doi: 10.1021/acs.jmedchem.7b00426
123. [123]
  Y. Song, P. Zhan, X. Li, et al., Curr. Med. Chem. 20 (2013) 815-832.
124. [124]
  D.P. Bondeson, A. Mares, I.E. Smith, et al., Nat. Chem. Biol. 11 (2015) 611-617. doi: 10.1038/nchembio.1858
125. [125]
  M. de Wispelaere, G. Du, K.A. Donovan, et al., Nat. Commun. 10 (2019) 3468.
126. [126]
  P. Zhan, X. Liu, Curr. Pharm. Des. 15 (2009) 1893-1917. doi: 10.2174/138161209788453266
127. [127]
  P. Zhan, X. Liu, Curr. Med. Chem. 20 (2013) 1743-1758. doi: 10.2174/0929867311320130011
128. [128]
  G. Wu, W.A. Zalloum, M.E. Meuser, et al., Eur. J. Med. Chem. 158 (2018) 478-492. doi: 10.1016/j.ejmech.2018.09.029
129. [129]
  L. Sun, P. Gao, G. Dong, et al., Eur. J. Med. Chem. 155 (2018) 714-724. doi: 10.1016/j.ejmech.2018.06.036
130. [130]
  P. Gao, X. Wang, L. Sun, et al., Chem. Biol. Drug Des. 93 (2019) 582-589. doi: 10.1111/cbdd.13455
131. [131]
  L. Wang, S.G. Sarafianos, Z. Wang, Acc. Chem. Res. 53 (2020) 218-230. doi: 10.1021/acs.accounts.9b00450
132. [132]
  Y. Yang, L. Cao, H. Gao, et al., J. Med. Chem. 62 (2019) 4056-4073. doi: 10.1021/acs.jmedchem.9b00091
133. [133]
  R.M. Palmer, A.G. Ferrige, S. Moncada, Nature 327 (1987) 524-526. doi: 10.1038/327524a0
134. [134]
  D. Basudhar, L.A. Ridnour, R. Cheng, et al., Coord. Chem. Rev. 306 (2016) 708-723. doi: 10.1016/j.ccr.2015.06.001
135. [135]
  D. Fukumura, S. Kashiwagi, R.K. Jain, Nat. Rev. Cancer 6 (2006) 521-534. doi: 10.1038/nrc1910
136. [136]
  A.J. Burke, F.J. Sullivan, F.J. Giles, S.A. Glynn, Carcinogenesis 34 (2013) 503-512. doi: 10.1093/carcin/bgt034
137. [137]
  V. Somasundaram, R. Nadhan, K.H. S, et al., Crit. Rev. Oncol. Hematol. 101 (2016) 184-192. doi: 10.1016/j.critrevonc.2016.03.004
138. [138]
  Z. Huang, J. Fu, Y. Zhang, J. Med. Chem. 60 (2017) 7617-7635. doi: 10.1021/acs.jmedchem.6b01672
139. [139]
  S. Mocellin, V. Bronte, D. Nitti, Med. Res. Rev. 27 (2007) 317-352. doi: 10.1002/med.20092
140. [140]
  M.M. Reynolds, S.D. Witzeling, V.B. Damodaran, et al., Biochem. Biophys. Res. Commun. 431 (2013) 647-651. doi: 10.1016/j.bbrc.2013.01.041
141. [141]
  H. Vahora, M.A. Khan, U. Alalami, A. Hussain, J. Cancer Prev. 21 (2016) 1-12. doi: 10.15430/JCP.2016.21.1.1
142. [142]
  A. Kamm, P. Przychodzen, A. Kuban-Jankowska, et al., Nitric Oxide 93 (2019) 102-114. doi: 10.1016/j.niox.2019.09.005
143. [143]
  J. Scicinski, B. Oronsky, S. Ning, et al., Redox Biol. 6 (2015) 1-8. doi: 10.1016/j.redox.2015.07.002
144. [144]
  C.A. Carter, B. Oronsky, S. Caroen, et al., Respir. Med. Case Rep. 18 (2016) 62-65.
145. [145]
  L.K. Keefer, ACS Chem. Biol. 6 (2011) 1147-1155. doi: 10.1021/cb200274r
146. [146]
  J.A. Hrabie, L.K. Keefer, Chem. Rev. 102 (2002) 1135-1154. doi: 10.1021/cr000028t
147. [147]
  J.E. Saavedra, A. Srinivasan, C.L. Bonifant, et al., J. Org. Chem. 66 (2001) 3090-3098. doi: 10.1021/jo0016529
148. [148]
  C. Chen, Y. Shi, S. Li, et al., Arch. Pharm. (Weinheim) 339 (2006) 366-371. doi: 10.1002/ardp.200500262
149. [149]
  N. Barraud, B.G. Kardak, N.R. Yepuri, et al., Angew. Chem. Int. Ed. 51 (2012) 9057-9060. doi: 10.1002/anie.201202414
150. [150]
  K.Sharma, A. Iyer, K. Sengupta, H. Chakrapani, Org. Lett.15 (2013) 2636-2639. doi: 10.1021/ol400884v
151. [151]
  Y. Zou, C. Yan, E.E. Knaus, et al., RSC Adv. 7 (2017) 18893-18899. doi: 10.1039/C7RA00401J
152. [152]
  J. Hou, Y. Pan, D. Zhu, et al., Nat. Chem. Biol. 15 (2019) 151-160. doi: 10.1038/s41589-018-0190-5
153. [153]
  M.L. O'Brien, K.D. Tew, Eur. J. Cancer 32a (1996) 967-978.
154. [154]
  S. Mahajan, W.M. Atkins, Cell. Mol. Life Sci. 62 (2005) 1221-1233. doi: 10.1007/s00018-005-4524-6
155. [155]
  Z. Huang, J. Wu, Y. Zou, et al., J. Med. Chem. 61 (2018) 1833-1844. doi: 10.1021/acs.jmedchem.7b01178
156. [156]
  R. Xue, J. Wu, X. Luo, et al., Org. Lett. 18 (2016) 5196-5199. doi: 10.1021/acs.orglett.6b02222
157. [157]
  X. Luo, J. Wu, T. Lv, et al., Org. Chem. Front. 4 (2017) 2445-2449. doi: 10.1039/C7QO00695K
158. [158]
  T. Lv, J. Wu, F. Kang, et al., Org. Lett. 20 (2018) 2164-2167. doi: 10.1021/acs.orglett.8b00423
159. [159]
  J.F. Quinn, M.R. Whittaker, T.P. Davis, J. Control. Release 205 (2015) 190-205. doi: 10.1016/j.jconrel.2015.02.007
160. [160]
  A.C. Midgley, Y. Wei, Z. Li, et al., Adv. Mater. 32 (2019) e1805818.
161. [161]
  H. Alimoradi, K. Greish, A.B. Gamble, G.I. Giles, Pharm. Nanotechnol. 7 (2019) 279-303. doi: 10.2174/2211738507666190429111306
162. [162]
  X. Jia, Y. Zhang, Y. Zou, et al., Adv. Mater. 30 (2018) e1704490. doi: 10.1002/adma.201704490
163. [163]
  Y. Hu, T. Lv, Y. Ma, et al., Nano Lett. 19 (2019) 2731-2738. doi: 10.1021/acs.nanolett.9b01093
164. [164]
  E.L. Sievers, P.D. Senter, Annu. Rev. Med. 64 (2013) 15-29. doi: 10.1146/annurev-med-050311-201823
165. [165]
  R.V. Chari, M.L. Miller, W.C. Widdison, Angew. Chem. Int. Ed. 53 (2014) 3796-3827.
166. [166]
  F. Sun, Y. Wang, X. Luo, et al., Cancer Res. 79 (2019) 3395-3405.
167. [167]
  R. Kumar, Curr. Med. Chem. 23 (2016) 2637-2642. doi: 10.2174/0929867323666160812150737
168. [168]
  X. Zhan, Y. Huang, S. Qian, Curr. Med. Chem. 25 (2018) 3435-3454. doi: 10.2174/0929867325666180221140745
169. [169]
  M.C. Franco, K.C. Ricart, A.S. Gonzalez, et al., J. Biol. Chem. 290 (2015) 19055-19066. doi: 10.1074/jbc.M115.663278
170. [170]
  S.N. Topkaya, V.H. Ozyurt, A.E. Cetin, S. Otles, Biosens. Bioelectron.102 (2018) 464-469. doi: 10.1016/j.bios.2017.11.061
171. [171]
  V. Fernando, X. Zheng, Y. Walia, et al., Antioxidants 8 (2019) 404-435. doi: 10.3390/antiox8090404
172. [172]
  M.M. Lerch, M.J. Hansen, G.M. van Dam, et al., Angew. Chem. Int. Ed. 55 (2016) 10978-10999. doi: 10.1002/anie.201601931
173. [173]
  V. San Miguel, C.G. Bochet, A. del Campo, J. Am. Chem. Soc.133 (2011) 5380-5388. doi: 10.1021/ja110572j
174. [174]
  K. Hull, J. Morstein, D. Trauner, Chem. Rev. 118 (2018) 10710-10747. doi: 10.1021/acs.chemrev.8b00037
175. [175]
  M.J. Hansen, W.A. Velema, M.M. Lerch, et al., Chem. Soc. Rev. 44 (2015) 3358-3377. doi: 10.1039/C5CS00118H
176. [176]
  W.A. Velema, W. Szymanski, B.L. Feringa, J. Am. Chem. Soc.136 (2014) 2178-2191. doi: 10.1021/ja413063e
177. [177]
  R. Horbert, B. Pinchuk, P. Davies, et al., ACS Chem. Biol. 10 (2015) 2099-2107. doi: 10.1021/acschembio.5b00174
178. [178]
  M.J. Hansen, F.M. Feringa, P. Kobauri, et al., J. Am. Chem. Soc. 140 (2018) 13136-13141. doi: 10.1021/jacs.8b04870
179. [179]
  Z. Li, K. Su, Z. Jiang, et al., J. Med. Chem. 62 (2019) 7583-7588. doi: 10.1021/acs.jmedchem.9b00688
180. [180]
  G. Bassolino, C. Nancoz, Z. Thiel, et al., Chem. Sci. 9 (2018) 387-391. doi: 10.1039/C7SC03627B
181. [181]
  R. Tamura, A. Balabanova, S.A. Frakes, et al., J. Med. Chem. 62 (2019) 1959-1970. doi: 10.1021/acs.jmedchem.8b01508
182. [182]
  A.S. Lubbe, W. Szymanski, B.L. Feringa, Chem. Soc. Rev. 46 (2017) 1052-1079. doi: 10.1039/C6CS00461J
183. [183]
  D. Lemoine, C. Habermacher, A. Martz, et al., Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 20813-20818. doi: 10.1073/pnas.1318715110
184. [184]
  N.J. Hauwert, T.A.M. Mocking, D. Da Costa Pereira, et al., J. Am. Chem. Soc.140 (2018) 4232-4243. doi: 10.1021/jacs.7b11422
185. [185]
  X. Gómez-Santacana, S.M. de Munnik, P. Vijayachandran, et al., Angew. Chem. Int. Ed. 57 (2018) 11608-11612. doi: 10.1002/anie.201804875
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