Citation: Chen Hu, Cheng Hongwei, Wu Wenying, Li Dengfeng, Mao Jingsong, Chu Chengchao, Liu Gang. The blooming intersection of transcatheter hepatic artery chemoembolization and nanomedicine[J]. Chinese Chemical Letters, ;2020, 31(6): 1375-1381. doi: 10.1016/j.cclet.2020.03.024 shu

The blooming intersection of transcatheter hepatic artery chemoembolization and nanomedicine

Chen Hu ^a,1 ,
Cheng Hongwei ^a,b,1 ,
Wu Wenying ^a,c,1 ,
Li Dengfeng ^a ,
Mao Jingsong ^a,b,*, ,
Chu Chengchao ^a,*, ,
Liu Gang ^a,*,

a.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
b.
Department of Radiology, Xiang'an Hospital of Xiamen University, Xiamen 361102, China
c.
Department of Radiological Intervention, The First Hospital of China Medical University, Shenyang 110001, China

Author Bio: Hu Chen is a PhD candidate in the Center for Molecular Imaging and Translational Medicine (CMITM) at Xiamen University under the supervision of Prof. Gang Liu. His scientific interests include nanomedicine, molecular imaging and interventional therapy

Jingsong Mao received his MD degree from China Medical University (China) in 2018. Recently, he is an associate chief physician in the radiology department of Xiang'an Hospital of Xiamen University. He specializes in radiological diagnosis and tumor vascular interventional therapy, and his interestsfocus on nanomedicine for cancer treatment
Chengchao Chu received his Master degree in chemistry from University of Jinan (China) in 2014 and PhD degree from Xiamen University (China) in 2018. Currently, he is a Postdoctor at Center for Molecular Imaging and Translational Medicine, Xiamen University. He focused his training on the preparation of metal-organic nano-materials and pure drug nanoparticles, andtheir appli-cations in molecular imaging, drug delivery, and X-ray induced dynamic therapy
Gang Liu received his MD degree from North Sichuan Medical College (China) in 2002 and PhD degree from Sichuan University (China) in 2009. Subsequently, He focused his training on nanomedicine and molecular imaging at the National Institutes of Biomedical Imaging and Bioengineering, National Institutes of Health. In 2012, he joined the Center for Molecular Imaging and Translational Medicine, Xiamen University. Currently, he is a full professor of Biomedical and Bioengineering and his research interests include biomaterials, theranostics and molecular imaging

maojingsong163@163.com

Chuchengchao0225@163.com

gangliu.cmitm@xmu.edu.cn

Received Date: 30 January 2020
Revised Date: 22 February 2020
Accepted Date: 2 March 2020
Available Online: 9 March 2020

Figures(4)

Transcatheter hepatic artery chemoembolization (TACE) is a universal treatment for patients with hepatocellular carcinoma (HCC) that inhibits tumor growth by cutting off the blood supply and provides chemotherapeutics locally to the tumor. The strategy of combining TACE formulation with image-guided ablation holds tremendous potential, but patient tolerance and undesired toxicity/immunosuppression remains a challenge. The application of nanotechnology in TACE opens new doors for the treatment of HCC. Strikingly, nanomaterials or nano-drugs dispersed in the TACE formulation can effectively improve the delivery efficiency of drugs by achieving both controlled and continuous release. In addition, the utilization of multifunctional nanoparticles can provide guidance and monitoring for various advanced imaging methods for TACE treatment, and can realize the combination therapy of thermal ablation, microwave ablation, in situ radiotherapy, and other therapies, greatly expanding the therapeutic strategies available for HCC treatment. Here, the current exploration of nanotechnology in TACE of HCC is briefly summarized and the challenges of TACE with nanoformulations for clinical translation are comprehensively discussed.
- Transcatheter hepatic artery,
- chemoembolization,
- Hepatocellular carcinoma,
- Nanomedicine,
- Theranostics,
- Combination therapy
1. [1]
  Y. A. Ghouri, I. Mian, J. Rowe, J. Carcinog. 16(2017) 1.
2. [2]
  T. Vos, A. A. Abajobir, K. H. Abate, et al., Lancet 390(2017) 1211-1259. doi: 10.1016/S0140-6736(17)32154-2
3. [3]
  A. Forner, M. Gilabert, J. Bruix, J. L. Raoul, Nat. Rev. Clin. Oncol. 11(2014) 525-535. doi: 10.1038/nrclinonc.2014.122
4. [4]
  A. Marcos-Alvarez, R. L. Jenkins, W. K. Washburn, et al., Arch. Surg. 131(1996) 292-298. doi: 10.1001/archsurg.1996.01430150070014
5. [5]
  R. Lencioni, Semin. Oncol. 39(2012) 503-509. doi: 10.1053/j.seminoncol.2012.05.004
6. [6]
  M. Tsurusaki, T. Murakami, Liver Cancer 4(2015) 165-175. doi: 10.1159/000367739
7. [7]
  J. M. Llovet, M. Ducreux, R. Lencioni, et al., J. Hepatol. 56(2012) 908-943. doi: 10.1016/j.jhep.2011.12.001
8. [8]
  P. Viveiros, A. Riaz, R. J. Lewandowski, et al., Cancers 11(2019) 1085. doi: 10.3390/cancers11081085
9. [9]
  J. P. Lai, A. Conley, B. S. Knudsen, et al., Histopathology 67(2015) 442-450. doi: 10.1111/his.12623
10. [10]
  K. Liu, X. L. Min, J. Peng, et al., J. Clin. Med. Res. 8(2016) 297-302. doi: 10.14740/jocmr2496w
11. [11]
  X. Chang, X. Lu, J. Guo, et al., Cancer Treat. Rev. 74(2019) 49-60. doi: 10.1016/j.ctrv.2018.08.006
12. [12]
  W. Fan, B. Yung, P. Huang, et al., Chem. Rev. 117(2017) 13566-13638. doi: 10.1021/acs.chemrev.7b00258
13. [13]
  Y. Shi, T. Lammers, Acc Chem, Res. 52(2019) 1543-1554. doi: 10.1021/acs.accounts.9b00148
14. [14]
  C. Chu, E. Ren, Y. Zhang, et al., Angew. Chem. Int. Ed. 58(2019) 269-272. doi: 10.1002/anie.201812482
15. [15]
  G. Lin, Y. Zhang, L. Zhang, et al., Nano Res. 13(2020) 238-245. doi: 10.1007/s12274-019-2606-2
16. [16]
  P. Lv, X. Liu, X. Chen, et al., Nano Lett. 19(2019) 2993-3001. doi: 10.1021/acs.nanolett.9b00145
17. [17]
  P. Zhang, L. Zhang, Z. Qin, et al., Adv. Mater. 30(2018) 1705350. doi: 10.1002/adma.201705350
18. [18]
  X. Zhang, Y. Zhang, Y. Zhang, et al., Biomater. Sci. 8(2020) 1575-1579. doi: 10.1039/C9BM02088H
19. [19]
  P. Zhang, J. Wang, H. Chen, et al., J. Am. Chem. Soc. 140(2018) 14980-14989. doi: 10.1021/jacs.8b09396
20. [20]
  Q. Lin, Z. Li, Q. Yuan, Chin. Chem. Lett. 30(2019) 1547-1556. doi: 10.1016/j.cclet.2019.06.016
21. [21]
  C. Yan, L. Shi, Z. Guo, et al., Chin. Chem. Lett. 30(2019) 1849-1855. doi: 10.1016/j.cclet.2019.08.038
22. [22]
  R. Tong, D. S. Kohane, Annu. Rev. Pharmacol. Toxicol. 56(2016) 41-57. doi: 10.1146/annurev-pharmtox-010715-103456
23. [23]
  J. He, C. Li, L. Ding, et al., Adv. Mater. 31(2019) 1902409. doi: 10.1002/adma.201902409
24. [24]
  X. Wang, J. Sheng, M. Yang, Chin. Chem. Lett. 30(2019) 533-540. doi: 10.1016/j.cclet.2018.10.010
25. [25]
  D. H. Kim, A. C. Larson, Interv. Oncol. 360(4) (2016) E173-E182.
26. [26]
  L. Xiao, M. Wang, Cell Biochem. Biophys. 70(2014) 269-272. doi: 10.1007/s12013-014-9893-8
27. [27]
  L. Shen, Y. Zhang, J. Zhang, et al., ACS Appl. Mater. Interfaces 11(2019) 20642-20648. doi: 10.1021/acsami.9b03110
28. [28]
  J. Zeng, L. Li, H. Zhang, et al., Theranostics 8(2018) 4591-4600. doi: 10.7150/thno.27379
29. [29]
  J. Li, M. Zhou, F. Liu, et al., Radiology 281(2016) 427-435. doi: 10.1148/radiol.2016152510
30. [30]
  F. Deschamps, T. Isoardo, S. Denis, et al., Acta Biomater. 87(2019) 177-186. doi: 10.1016/j.actbio.2019.01.054
31. [31]
  D. Bannerman, W. Wan, Expert Opin. Drug Deliv. 13(2016) 1289-1300. doi: 10.1080/17425247.2016.1192122
32. [32]
  M. F. Hsu, Y. S. Tyan, Y. C. Chien, et al., Sci. Rep. 8(2018) 731. doi: 10.1038/s41598-018-19191-7
33. [33]
  S. Y. Lee, J. W. Choi, J. Y. Lee, et al., Drug Deliv. 25(2018) 1472-1483. doi: 10.1080/10717544.2018.1480673
34. [34]
  C. Chen, R. Tian, Y. Zeng, et al., Bioconjug. Chem. 31(2020) 276-292. doi: 10.1021/acs.bioconjchem.9b00734
35. [35]
  J. Qian, E. Oppermann, A. Tran, et al., World J. Gastroenterol. 22(2016) 5042-5049. doi: 10.3748/wjg.v22.i21.5042
36. [36]
  R. T. Poon, H. Ngan, C. M. Lo, et al., J. Surg. Oncol. 73(2000) 109-114. doi: 10.1002/(SICI)1096-9098(200002)73:2<109::AID-JSO10>3.0.CO;2-J
37. [37]
  A. Parvinian, L. C. Casadaban, Z. Z. Hauck, et al., Diagn. Interv. Radiol. 21(2015) 235-240. doi: 10.5152/dir.2014.14394
38. [38]
  W. Cai, Y. Zhang, J. Wang, et al., Chem. Eng. J. 380(2020) 122473. doi: 10.1016/j.cej.2019.122473
39. [39]
  Y. Shi, J. Wang, J. Liu, et al., Biomaterials 233(2020) 119753. doi: 10.1016/j.biomaterials.2019.119753
40. [40]
  M. J. Jeon, A. C. Gordon, A. C. Larson, et al., Biomaterials 88(2016) 25-33. doi: 10.1016/j.biomaterials.2016.02.021
41. [41]
  Q. Wang, K. Qian, S. Liu, et al., Biomacromolecules 16(2015) 1240-1246. doi: 10.1021/acs.biomac.5b00027
42. [42]
  E. Y. Chung, H. M. Kim, G. H. Lee, et al., Carbohydr. Polym. 90(2012) 1725-1731. doi: 10.1016/j.carbpol.2012.07.058
43. [43]
  H. Wang, X. Y. Qin, Z. Y. Li, et al., Int. J. Pharm. 511(2016) 831-839. doi: 10.1016/j.ijpharm.2016.07.028
44. [44]
  D. H. Kim, J. Chen, R. A. Omary, et al., Theranostics 5(2015) 477-488. doi: 10.7150/thno.10823
45. [45]
  P. Pouponneau, J. C. Leroux, S. Martel, Biomaterials 30(2009) 6327-6332. doi: 10.1016/j.biomaterials.2009.08.005
46. [46]
  P. Pouponneau, J. C. Leroux, G. Soulez, et al., Biomaterials 32(2011) 3481-3486. doi: 10.1016/j.biomaterials.2010.12.059
47. [47]
  P. Pouponneau, G. Soulez, G. Beaudoin, et al., Cardiovasc. Intervent. Radiol. 37(2014) 784-790. doi: 10.1007/s00270-013-0770-4
48. [48]
  H. Ruan, Q. Hu, D. Wen, et al., Adv. Mater. 31(2019) 1806957. doi: 10.1002/adma.201806957
49. [49]
  Z. Meng, X. Zhou, J. Xu, et al., Adv. Mater. 31(2019) 1900927.
50. [50]
  S. Yu, C. Wang, J. Yu, et al., Adv. Mater. 30(2018) 1801527. doi: 10.1002/adma.201801527
51. [51]
  Y. Chao, L. Xu, C. Liang, et al., Nat. Biomed. Eng. 2(2018) 611-621. doi: 10.1038/s41551-018-0262-6
52. [52]
  Q. Chen, C. Wang, X. Zhang, et al., Nat. Nanotechnol. 14(2019) 89-97.
53. [53]
  I. S. Smolkova, N. E. Kazantseva, K. N. Makoveckaya, et al., Mater. Sci. Eng. C 48(2015) 632-641. doi: 10.1016/j.msec.2014.12.046
54. [54]
  Q. Liu, Y. Qian, P. Li, et al., Theranostics 8(2018) 785-799. doi: 10.7150/thno.21491
55. [55]
  J. Mao, S. Tang, D. Hong, et al., Nanoscale 9(2017) 3429-3439. doi: 10.1039/C6NR09862B
56. [56]
  Y. You, Z. Wang, H. Ran, et al., Nanoscale 8(2016) 4324-4339. doi: 10.1039/C5NR08292G
57. [57]
  G. Niu, X. Chen, Curr. Drug Target. 11(2010) 1000-1017. doi: 10.2174/138945010791591395
58. [58]
  J. M. Llovet, M. I. Real, X. Montaña, et al., Lancet 359(2002) 1734-1739. doi: 10.1016/S0140-6736(02)08649-X
59. [59]
  C. M. Lo, H. Ngan, W. K. Tso, et al., Hepatology 35(2002) 1164-1171. doi: 10.1053/jhep.2002.33156
60. [60]
  X. B. Liu, Q. Cheng, W. Geng, et al., Artif. Cells Nanomed. Biotechnol. 42(2014) 229-236. doi: 10.3109/21691401.2013.808647
61. [61]
  H. Chen, F. Li, Y. Yao, et al., Theranostics 9(2019) 90-103. doi: 10.7150/thno.30259
62. [62]
  J. Li, W. Shang, Y. Li, et al., Int. J. Nanomedicine 13(2018) 5925-5936. doi: 10.2147/IJN.S173914
63. [63]
  G. Yang, J. Tian, C. Chen, et al., Chem. Sci. 10(2019) 5766-5772. doi: 10.1039/C9SC00985J
64. [64]
  X. Qian, Y. Zheng, Y. Chen, et al., Adv. mater. 28(2016) 8097-8129. doi: 10.1002/adma.201602012
65. [65]
  Y. Wang, W. Shang, M. Niu, et al., Int. J. Nanomedicine 14(2019) 3705-3722. doi: 10.2147/IJN.S196959
66. [66]
  M. Goldberg, Nat. Rev. Cancer 19(2019) 587-602. doi: 10.1038/s41568-019-0186-9
67. [67]
  Q. Song, Y. Yin, L. Shang, et al., Nano Lett. 17(2017) 6366-6375. doi: 10.1021/acs.nanolett.7b03186
68. [68]
  Q. Chen, L. Xu, C. Liang, et al., Nat. Commun. 7(2016) 13193. doi: 10.1038/ncomms13193
69. [69]
  K. Lu, C. He, N. Guo, et al., Nat. Biomed. Eng. 2(2018) 600-610. doi: 10.1038/s41551-018-0203-4
70. [70]
  H. Takaki, N. Imai, T. T. Contessa, et al., J. Vasc. Interv. Radiol. 27(2016) 1561-1568. doi: 10.1016/j.jvir.2016.01.150
71. [71]
  M. Z. Noman, G. Desantis, B. Janji, et al., J. Exp. Med. 211(2014) 781-790. doi: 10.1084/jem.20131916
1. [1]
  Zhiyu Yu , Xiang Luo , Cheng Zhang , Xin Lu , Xiaohui Li , Pan Liao , Zhongqiu Liu , Rong Zhang , Shengtao Wang , Zhiqiang Yu , Guochao Liao . Mitochondria-targeted carrier-free nanoparticles based on dihydroartemisinin against hepatocellular carcinoma. Chinese Chemical Letters, 2024, 35(10): 109519-. doi: 10.1016/j.cclet.2024.109519
2. [2]
  Qiuye Wang , Yabing Sun , Liangxue Lai , Haijing Cui , Yonglong Ye , Ming Yang , Weihao Zhu , Bo Yuan , Quanliang Mao , Wenzhi Ren , Aiguo Wu . MMP-9-responsive probe for fluorescence-magnetic resonance dual-mode imaging of hepatocellular carcinoma models with different metastatic capacities. Chinese Chemical Letters, 2025, 36(4): 110212-. doi: 10.1016/j.cclet.2024.110212
3. [3]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
4. [4]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
5. [5]
  Liangliang Jia , Ye Hong , Xinyu He , Ying Zhou , Liujiao Ren , Hongjun Du , Bin Zhao , Bin Qin , Zhe Yang , Di Gao . Fighting hypoxia to improve photodynamic therapy-driven immunotherapy: Alleviating, exploiting and disregarding. Chinese Chemical Letters, 2025, 36(2): 109957-. doi: 10.1016/j.cclet.2024.109957
6. [6]
  Zhongyu Wang , Lijun Wang , Huaixin Zhao . DNA-based nanosystems to generate reactive oxygen species for nanomedicine. Chinese Chemical Letters, 2024, 35(11): 109637-. doi: 10.1016/j.cclet.2024.109637
7. [7]
  Yating Zheng , Yulan Huang , Jing Luo , Xuqi Peng , Xiran Gui , Gang Liu , Yang Zhang . Supercritical fluid technology: A game-changer for biomacromolecular nanomedicine preparation and biomedical application. Chinese Chemical Letters, 2024, 35(7): 109169-. doi: 10.1016/j.cclet.2023.109169
8. [8]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
9. [9]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
10. [10]
  Hao Sun , Shengke Li , Qian Liu , Minzan Zuo , Xueqi Tian , Kaiya Wang , Xiao-Yu Hu . Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy. Chinese Chemical Letters, 2025, 36(3): 109999-. doi: 10.1016/j.cclet.2024.109999
11. [11]
  Jun Xiong , Ke-Ke Chen , Neng-Bin Xie , Wei Chen , Wen-Xuan Shao , Tong-Tong Ji , Si-Yu Yu , Yu-Qi Feng , Bi-Feng Yuan . Demethylase-assisted site-specific detection of N¹-methyladenosine in RNA. Chinese Chemical Letters, 2024, 35(5): 108953-. doi: 10.1016/j.cclet.2023.108953
12. [12]
  Manoj Kumar Sarangi , L․D Patel , Goutam Rath , Sitansu Sekhar Nanda , Dong Kee Yi . Metal organic framework modulated nanozymes tailored with their biomedical approaches. Chinese Chemical Letters, 2024, 35(11): 109381-. doi: 10.1016/j.cclet.2023.109381
13. [13]
  Zhi Li , Wenpei Li , Shaoping Jiang , Chuan Hu , Yuanyu Huang , Maxim Shevtsov , Huile Gao , Shaobo Ruan . Legumain-triggered aggregable gold nanoparticles for enhanced intratumoral retention. Chinese Chemical Letters, 2024, 35(7): 109150-. doi: 10.1016/j.cclet.2023.109150
14. [14]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
15. [15]
  Huijiao Fu , Peiqin Liang , Qianwen Chen , Yan Wang , Guang Li , Xuzi Cai , Shengtao Wang , Kun Chen , Shengying Shi , Zhiqiang Yu , Xuefeng Wang . COX-2 blocking therapy in cisplatin chemosensitization of ovarian cancer: An allicin-based nanomedicine approach. Chinese Chemical Letters, 2024, 35(8): 109241-. doi: 10.1016/j.cclet.2023.109241
16. [16]
  An Lu , Yuhao Guo , Yi Yan , Lin Zhai , Xiangyu Wang , Weiran Cao , Zijie Li , Zhixia Zhao , Yujie Shi , Yuanjun Zhu , Xiaoyan Liu , Huining He , Zhiyu Wang , Jian-Cheng Wang . Nanomedicine integrating the lipidic derivative of 5-fluorouracil, miriplatin and PD-L1 siRNA for enhancing tumor therapy. Chinese Chemical Letters, 2024, 35(6): 108928-. doi: 10.1016/j.cclet.2023.108928
17. [17]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
18. [18]
  Shuheng Zhang , Yuanyuan Zhang , Wanyu Wang , Yuzhu Hu , Xinchuan Chen , Bilan Wang , Xiang Gao . A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy. Chinese Chemical Letters, 2024, 35(12): 109658-. doi: 10.1016/j.cclet.2024.109658
19. [19]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
20. [20]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511

Get Citation

PDF

XML

Metrics

PDF Downloads(6)
Abstract views(944)
HTML views(8)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142