Citation: Xie Hui, Di Kaili, Huang Rongrong, Khan Adeel, Xia Yanyan, Xu Hongpan, Liu Chang, Tan Tingting, Tian Xinyu, Shen Han, He Nongyue, Li Zhiyang. Extracellular vesicles based electrochemical biosensors for detection of cancer cells: A review[J]. Chinese Chemical Letters, ;2020, 31(7): 1737-1745. doi: 10.1016/j.cclet.2020.02.049 shu

Extracellular vesicles based electrochemical biosensors for detection of cancer cells: A review

Xie Hui ^a,b ,
Di Kaili ^c ,
Huang Rongrong ^c ,
Khan Adeel ^d ,
Xia Yanyan ^c ,
Xu Hongpan ^c ,
Liu Chang ^c ,
Tan Tingting ^c ,
Tian Xinyu ^c ,
Shen Han ^a,*, ,
He Nongyue ^d,e,**, ,
Li Zhiyang ^a,b,*,

a.
Department of Clinical Laboratory, Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical University, Nanjing 210008, China
b.
Department of Clinical Laboratory, Yizheng Hospital of Nanjing Drum Tower Hospital Group, Yizheng 211900, China
c.
Department of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
d.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, National Demonstration Center for Experimental Biomedical Engineering Education(Southeast University), Southeast University, Nanjing 210096, China
e.
Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China

^**

shenhan10366@sina.com

nyhe@seu.edu.cn

lizhiyangcn@qq.com

Received Date: 24 December 2019
Revised Date: 23 February 2020
Accepted Date: 24 February 2020
Available Online: 25 February 2020

Figures(13)

Extracellular vesicles (EVs) derived from cancer cells are considered as ideal biomarker for liquid biopsy in cancer diagnosis, and are stable and abundant. Electrochemical methods for the detection of EVs are preferred over conventional methods such as Western blotting and enzyme-linked immunosorbent assay for their high sensitivity and real-time detection. This article summaries studies proposing the electrochemical methods utilizing immunological and molecular methodologies for detecting EVs derived biomacromolecules such as miRNAs and transmembrane protein for cancer diagnosis. Moreover, the electrochemical detection methods are compared and future prospects for the development of electrochemical methods for EVs detection are concluded.
- Cancerous,
- Extracellular vesicles,
- Electrochemical,
- Biosensors,
- Detection
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