Citation: Lei Zhou, Chang Du, Rong Zhang, Changming Dong. Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy[J]. Chinese Chemical Letters, ;2021, 32(1): 561-564. doi: 10.1016/j.cclet.2020.02.043 shu

Stimuli-responsive dual drugs-conjugated polydopamine nanoparticles for the combination photothermal-cocktail chemotherapy

Lei Zhou ^{a, 1} ,
Chang Du ^{a, b, 1} ,
Rong Zhang ^{b, *,} ,
Changming Dong ^{a, *,}

a.
School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China
b.
Joint Research Center for Precision Medicine, Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian Central Hospital, Shanghai 201499, China

rongzhang@163.com

cmdong@sjtu.edu.cn

Received Date: 10 December 2019
Revised Date: 16 January 2020
Accepted Date: 20 February 2020
Available Online: 21 February 2020

Figures(4)

We developed one-pot aqueous copolymerization of two dopamine prodrugs to prepare dual drugs-conjugated polydopamine nanoparticles (PDOXCBs), which integrated near infrared (NIR)-mediated photothermal effect with cocktail chemotherapy into one copolymer nanoparticle. Upon a mild NIR irradiation (808 nm, 1 W/cm², 10 min), PDOXCBs gradually heated aqueous solution over 12.8–13.9 ℃, which accordingly enhanced in vitro dual doxorubicin (DOX) and chlorambucil (CB) drug-release with assistance of the other stimuli of pH 5.0 and 10 mmol/L D,L-dithiothreitol (DTT). The combination photothermal-cocktail chemotherapy (PTT－CCT) treatment based on PDOXCB₂₇ plus NIR irradiation gave a highly lowered half maximal inhibitory concentration (IC₅₀) of 2.23 μg/mL and a combination index of 0.36, displaying a superior synergistic effect between PTT and CCT in vitro.
- Near infrared,
- Polymer drug conjugate,
- Cocktail chemotherapy,
- Photothermal therapy,
- Combination therapy
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沈阳化工大学材料科学与工程学院沈阳 110142