Citation: Xue Feng, Jiaxin Tian, Ying Sun, Huayou Hu, Mingzhu Lu, Yuhe Kan, Danjun Fang, Chao Wang. Weakly coordinating group directed rhodium-catalyzed unconventional site-selective C–H olefination of indolizines at the 8-position[J]. Chinese Chemical Letters, ;2021, 32(1): 470-474. doi: 10.1016/j.cclet.2020.02.039 shu

Weakly coordinating group directed rhodium-catalyzed unconventional site-selective C–H olefination of indolizines at the 8-position

Xue Feng ^{a, b} ,
Jiaxin Tian ^b ,
Ying Sun ^b ,
Huayou Hu ^{b, *,} ,
Mingzhu Lu ^b ,
Yuhe Kan ^b ,
Danjun Fang ^c ,
Chao Wang ^{a, *,}

a.
School of Material Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China
b.
Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials, School of Chemistry and Chemical Engineering, Huaiyin Normal University, Huaian 223300, China
c.
Department of Pharmacology, Nanjing Medical University, Nanjing 210029, China

HauyouHu@hytc.edu.cn

wangchao@swust.edu.cn

Received Date: 13 January 2020
Revised Date: 3 February 2020
Accepted Date: 20 February 2020
Available Online: 20 February 2020

Figures(7)

A rhodium-catalyzed directing group promoted selective C–H olefination reaction of indolizines at the 8-position is reported. Di-olefination at 2,8-positions also achieved with silver hexafluoroantimonate as an additive under similar reaction conditions. Weakly coordinating groups, such as ketone, aldehyde, amide and ester, were used as directing groups. The ester group can be removed under acid conditions and therefore is used as a traceless directing group.
- Rhodium-catalyzed,
- C–H olefination,
- Indolizine,
- Weakly coordinating directing group,
- Unconventional site-selectivity
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