Citation: Yu Wenqi, Maxim Shevtsov, Chen Xianchun, Gao Huile. Advances in aggregatable nanoparticles for tumor-targeted drug delivery[J]. Chinese Chemical Letters, ;2020, 31(6): 1366-1374. doi: 10.1016/j.cclet.2020.02.036 shu

Advances in aggregatable nanoparticles for tumor-targeted drug delivery

Yu Wenqi ^a ,
Maxim Shevtsov ^c ,
Chen Xianchun ^b,*, ,
Gao Huile ^a,*,

a.
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, China
b.
College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China
c.
Institute of Cytology of the Russian Academy of Sciences(RAS), St. Petersburg 194064, Russia

chenxianchun@scu.edu.cn

gaohuile@scu.edu.cn

gaohuilescu@163.com

Received Date: 12 January 2020
Revised Date: 17 February 2020
Accepted Date: 18 February 2020
Available Online: 20 February 2020

Figures(7)

Recent days, aggregatable nanoparticles, which can specifically respond to certain stimulus, have shown great potential in tumor-targeted drug delivery with prolonged retention and deeper penetration. In this review, we summarize recent advances in design of aggregatable nanoparticles by different stimuli. Internal (pH and enzyme) and external (light, temperature and ROS) stimuli are introduced for a comprehensive description. Moreover, the aggregated nanoparticles usually exhibit photothermal, photoacoustic, PET and enhanced MRI contrast, which is also described. In the end, we discuss about the potential applications and challenges for the future clinical translation.
- Stimuli-responsive nanoparticles,
- Size aggregation,
- Tumor-targeted drug delivery,
- Transformation,
- Microenvironment modulation
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