Citation: Sun Min, Hu Hankun, Sun Leming, Fan Zhen. The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability: A mini-review[J]. Chinese Chemical Letters, ;2020, 31(7): 1729-1736. doi: 10.1016/j.cclet.2020.02.035 shu

The application of biomacromolecules to improve oral absorption by enhanced intestinal permeability: A mini-review

Sun Min ^a ,
Hu Hankun ^b,*, ,
Sun Leming ^c,*, ,
Fan Zhen ^a,d,**,

a.
Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, Shanghai 201804, China
b.
Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
c.
School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China
d.
Institute for Advanced Study, Tongji University, Shanghai 200092, China

^**

huhankun@whu.edu.cn

lmsun@nwpu.edu.cn

sun.1342@osu.edu

fanzhen2018@tongji.edu.cn

Received Date: 8 December 2019
Revised Date: 17 February 2020
Accepted Date: 18 February 2020
Available Online: 19 February 2020

Figures(7)

Oral administration has been widely regarded as the most convenient, quick and safe approach compared to other routes of drug delivery. However, oral absorption of drugs is often limited due to rigorous environments and complex obstacles in gastrointestinal tract. Having received considerable attention, biomacromolecules have been applied for oral drug delivery to improve the bioavailability, which could be attributed to its stability and unique bioactivities, including intestinal adhesion, opening of epithelial tight junctions, inhibiting cell efflux and regulating relative protein expression. Specifically, enhancing intestinal permeability has been regarded as a promising strategy for improving bioavailability of oral drug delivery. In this review, a series of biomacromolecules and the related mechanisms of increasing intestinal permeability for enhanced oral bioavailability are comprehensively classified and elucidated. In addition, recent advances in biomacromolecules based oral delivery and related future directions are mentioned and predicted in this review article.
- Biomacromolecules,
- Intestinal permeability,
- Oral administration,
- Transported ratio,
- Delivery barriers
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