Citation: Shen Lijun, Zhou Tianjiao, Fan Yatong, Chang Xin, Wang Yi, Sun Jianguo, Xing Lei, Jiang Hulin. Recent progress in tumor photodynamic immunotherapy[J]. Chinese Chemical Letters, ;2020, 31(7): 1709-1716. doi: 10.1016/j.cclet.2020.02.007 shu

Recent progress in tumor photodynamic immunotherapy

Shen Lijun ^a,1 ,
Zhou Tianjiao ^a,1 ,
Fan Yatong ^a ,
Chang Xin ^a ,
Wang Yi ^a ,
Sun Jianguo ^e,*, ,
Xing Lei ^a,b,c,d,*, ,
Jiang Hulin ^a,b,c,d,*,

a.
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China
b.
Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, China Pharmaceutical University, Nanjing 210009, China
c.
Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China
d.
Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing 210009, China
e.
Key Lab of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China

jgsun@cpu.edu.cn

xinglei6xl@163.com

jianghulin3@163.com

Received Date: 5 February 2020
Revised Date: 5 February 2020
Accepted Date: 6 February 2020
Available Online: 6 February 2020

Figures(4)

Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment, which can directly destroy local tumor cells due to the generation of cytotoxic singlet oxygen and reactive oxygen species (ROS) in the tumor cells. Intriguingly, PDT-mediated cell death is also associated with anti-tumor immune response. However, immunosuppression of tumor microenvironment is able to limit the immune response induced by PDT, it is therefore necessary to combine with immunocheckpoint inhibitor and immunoadjuvant for synergistic treatment of tumors. Herein, the recent advances of PDT, immunotherapy, and photodynamic immunotherapy are reviewed.
- Cancer therapy,
- Photodynamic therapy,
- Immunotherapy,
- Reactive oxygen species,
- Singlet oxygen
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沈阳化工大学材料科学与工程学院沈阳 110142