Citation: Zhao Hong, Yang Xiao-Hua, Pan Yu-Chen, Tian Han-Wen, Hu Xin-Yue, Guo Dong-Sheng. Inhibition of insulin fibrillation by amphiphilic sulfonatocalixarene[J]. Chinese Chemical Letters, ;2020, 31(7): 1873-1876. doi: 10.1016/j.cclet.2020.01.042 shu

Inhibition of insulin fibrillation by amphiphilic sulfonatocalixarene

a.
College of Chemistry, Key Laboratory of Functional Polymer Materials(Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
b.
Research Institute of Petroleum Engineering, Sinopec, Beijing 100101, China

huxinyue@nankai.edu.cn

dshguo@nankai.edu.cn

Received Date: 26 November 2019
Revised Date: 6 January 2020
Accepted Date: 19 January 2020
Available Online: 20 January 2020

Figures(4)

Insulin fibrillation poses a variety of problems in biomedical and biotechnological applications of insulin. Inhibiting insulin fibrillation is highly on demand to address those problems. We herein demonstrate the capability of amphiphilic sulfonatocalixarene to inhibit insulin fibrillation. The amphiphilic assembly of p-sulfonatocalix[4]arene tetra dodecyl ether exhibits much better efficiency on inhibiting insulin fibrillation, with respect to p-sulfonatocalix[4]arene and sodium dodecyl benzenesulphonate. The pronounced inhibition effect results from both the preorganized scaffold of calixarene and the amphiphilic assembly.
- Supramolecular chemistry,
- Calixarene,
- Self-assembly,
- Molecular recognition,
- Insulin fibrillation
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1.
沈阳化工大学材料科学与工程学院沈阳 110142