Citation: Deng Yangwei, Chen Hui, Tao Xinfeng, Trépout Sylvain, Ling Jun, Li Min-Hui. Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) and their oxidation-sensitive polymersomes[J]. Chinese Chemical Letters, ;2020, 31(7): 1931-1935. doi: 10.1016/j.cclet.2019.12.026 shu

Synthesis and self-assembly of poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) and their oxidation-sensitive polymersomes

Deng Yangwei ^a,b ,
Chen Hui ^a ,
Tao Xinfeng ^a,e ,
Trépout Sylvain ^d ,
Ling Jun ^b,*, ,
Li Min-Hui ^a,c,**,

a.
Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, Paris 75005, France
b.
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
c.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China
d.
Institut Curie, Inserm US43, University Paris Saclay, Orsay Cedex 91405, France
e.
Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China

^**

lingjun@zju.edu.cn

min-hui.li@chimieparistech.psl.eu

Received Date: 23 November 2019
Revised Date: 16 December 2019
Accepted Date: 17 December 2019
Available Online: 18 December 2019

Figures(4)

Amphiphilic block copolymers poly(ethylene glycol)-block-poly(N-3-(methylthio)propyl glycine) (PEG-b-PMeSPG) were synthesized via ring-opening polymerization of N-3-(methylthio)propyl glycine N-thiocarboxyanhydride (MeSPG-NTA) initiated by amino-terminated PEG. The self-assemblies of three PEG-b-PMeSPG copolymers with different PMeSPG block lengths were first prepared by nanoprecipitation method using THF and DMF, respectively, as the organic solvent, and their morphologies were studied by Cryo-EM and DLS. To prepare polymersomes loaded with glucose oxidase (GOx), double emulsion method followed by extrusion treatment was employed. The oxidation-responsive disruption of polymersomes was achieved upon the introduction of glucose because of the oxidants generated in-situ by GOx/glucose.
- Polypeptoid,
- Self-assembly,
- Polymersome,
- Oxidation-responsive,
- Glucose oxidase
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