Citation: Zou Liang-Hua, Fan Min, Wang Lu, Liu Chao. Hetero diacylation of 1, 1-diborylalkanes: Practical synthesis of 1, 3-diketones[J]. Chinese Chemical Letters, ;2020, 31(7): 1911-1913. doi: 10.1016/j.cclet.2019.12.016 shu

Hetero diacylation of 1, 1-diborylalkanes: Practical synthesis of 1, 3-diketones

Zou Liang-Hua ^a,*, ,
Fan Min ^a,b ,
Wang Lu ^b,*, ,
Liu Chao ^b,*,

a.
Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China
b.
State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics(LICP), Chinese Academy of Sciences, Lanzhou 730000, China

zoulianghua@jiangnan.edu.cn

wanglu@licp.cas.cn

chaoliu@licp.cas.cn

Received Date: 22 October 2019
Revised Date: 25 November 2019
Accepted Date: 9 December 2019
Available Online: 13 December 2019

Figures(5)

An efficient protocol for the synthesis of asymmetric 1, 3-diketones was reported through diacylation of 1, 1-diborylalkanes using two different acyl sources. In this transformation, an enolate boron species was initially formed by introducing an acyl group, then it was trapped by another acyl group to form 1, 3-diketone. This method not only provided the gateway to obtain a series of 1, 3-diketones, but also afforded an operationally simple and efficient access to pyrazoles and isoxazoles.
- 1, 1-Diborylalkanes,
- Diacylation,
- Enolate boron species,
- Boron-stabilized carbanion intermediates,
- 1, 3-Diketones
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