Citation: Huang Yuanqiong, Lv Xueli, Song Hongjian, Liu Yuxiu, Wang Qingmin. Rh(III)-catalyzed C8 arylation of quinoline N-oxides with arylboronic acids[J]. Chinese Chemical Letters, ;2020, 31(6): 1572-1575. doi: 10.1016/j.cclet.2019.11.028 shu

Rh(III)-catalyzed C8 arylation of quinoline N-oxides with arylboronic acids

Huang Yuanqiong ^a ,
Lv Xueli ^a ,
Song Hongjian ^a,*, ,
Liu Yuxiu ^a ,
Wang Qingmin ^a,b,*,

a.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China
b.
Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Tianjin 300071, China

songhongjian@nankai.edu.cn

wangqm@nankai.edu.cn

Received Date: 14 September 2019
Revised Date: 16 November 2019
Accepted Date: 18 November 2019
Available Online: 19 November 2019

Figures(6)

Herein, we report the first Rh^III-catalyzed regioselective C8 arylation of quinoline N-oxides with commercially available arylboronic acids as coupling partners. This procedure is simple, and the reaction shows perfect regioselectivity, a broad substrate scope, and isolated yields of up to 92%. We demonstrate the utility of the reaction by using it for late-stage functionalization of a fungicide.
- Rh^III-catalyzed,
- C8 arylation,
- Quinoline N-oxides,
- Arylboronic acids,
- Regioselectivity
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