Citation: Wang Yuemei, Feng Wei, Chen Yu. Chemistry of two-dimensional MXene nanosheets in theranostic nanomedicine[J]. Chinese Chemical Letters, ;2020, 31(4): 937-946. doi: 10.1016/j.cclet.2019.11.016 shu

Chemistry of two-dimensional MXene nanosheets in theranostic nanomedicine

Wang Yuemei ^a,b ,
Feng Wei ^a,*, ,
Chen Yu ^a,b,*,

a.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
b.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Science, Beijing 100049, China

Author Bio: Yuemei Wang obtained her bachelor's degree in biomedical engineering from Southwest Jiaotong University in 2018. She is currently a master candidate under the supervisor of Prof. Yu Chen in Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS). Her current research interest focuses on 2D nanomaterials in biomedical applications and nanocatalytic medicine
Wei Feng received his Ph.D. degree in Chemistry from Donghua University in 2016. He is currently conducting his postdoctoral research with Prof. Yu Chen at Shanghai Institute of Ceramics, Chinese Academy of Sciences (SICCAS). His current research interests include the development of multifunctional nanostructures for biomedical applications
Yu Chen received his Ph.D.degreeat SICCAS.Heisnowthe full professor in SICCAS. His research includes the design, synthesis and biomedical applications of mesoporous silica/organosilica, 2D biomaterials (graphene, metal oxides, TMDCs, and MXenes) and 3D composite bioimplants, including mesoporous material for nanocatalytic medicine, drug delivery, molecular imaging, ultrasound therapy, sonodynamic therapy, cardiac therapy, non-virus gene delivery vehicles and in-situ localized tumour therapy.He has published more than 160 scientific papers in nanomedicine field with a total citation of more than 12, 000 times (h-index:59). He is 2018 Highly Cited Researcher by Clarivate Analytics, Web of Science

fengwei@mail.sic.ac.cn

chenyu@mail.sic.ac.cn

Received Date: 14 October 2019
Revised Date: 4 November 2019
Accepted Date: 11 November 2019
Available Online: 14 November 2019

Figures(9)

Transition metal carbide, carbonitride and nitride MXenes, as the emerging two-dimensional (2D) nanomaterials, have aroused burgeoning research interest in a broad range of applications ranging from energy conversion to biomedicines attributing to their distinctive planar nanostructure, physiochemical properties and biological effects. They are featured with fascinating electronic, optical, magnetic, mechanical and thermal properties, which exert significant roles in biomedical applications of 2D MXenes. In this review, we briefly summarize the recent research progress of 2D MXenes and highlight their intrinsic chemistry in theranostic nanomedicines, focusing on the synthetic chemistry for MXenes construction, surface chemistry for surface engineering, physiochemical property for theranostic application and biological chemistry for biosafety evaluation. Furthermore, based on the current achievements on MXenes, their potential research direction, critical challenges and future development in biomedicine are also discussed. It is highly expected that 2D MXene-based nanosystems would have a broad application prospect in theranostic biomedicine provided the current facing critical issues and challenges are adequately solved.
- MXenes,
- Two-dimensional materials,
- Nanomedicine,
- Cancer,
- Theranostic
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沈阳化工大学材料科学与工程学院沈阳 110142