Citation: Chen Xinghan, Tan Pengfei, Wen Ya, Zhou Wencheng, Cen Ying, You Chao, Tan Lin, Tian Meng. Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing[J]. Chinese Chemical Letters, ;2020, 31(6): 1499-1503. doi: 10.1016/j.cclet.2019.11.006 shu

Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing

Chen Xinghan ^a,1 ,
Tan Pengfei ^b,1 ,
Wen Ya ^b ,
Zhou Wencheng ^a ,
Cen Ying ^a ,
You Chao ^c ,
Tan Lin ^b,d,*, ,
Tian Meng ^a,c,**,

a.
Department of Burns and Plastic Surgery, and Neurosurgery Research Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China
b.
College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China
c.
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, China
d.
Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China

^**

tanlinou@scu.edu.cn

tianmong007@gmail.com

Received Date: 30 August 2019
Revised Date: 2 November 2019
Accepted Date: 5 November 2019
Available Online: 6 November 2019

Figures(6)

Surgical suture is commonly used in clinic due to its action in accelerating the process of wound healing. However, difficultly handling in minimally invasive surgery and bacteria-induced infection usually limit its use in a wide range of applications. Here, we report a facile scalable strategy to fabricate surgical sutures with shape memory function and antibacterial activity for wound healing. Specifically, a shape memory polyurethane (SMPU) with a transition temperature (T_trans) at 41.3 ℃ was synthesized by adjusting the mole ratio of the hard/soft segment, and then the shape memory surgical sutures containing polyhexamethylene biguanide hydrochloride (PHMB) as a model drug for antibacterial activity were fabricated by a facile scalable one-step wet-spinning approach, in which PHMB was directly dissolved in the coagulation bath that enable its loading into the sutures through the dual diffusion during the phase separation. The prepared sutures were characterized by their morphology, mechanical properties, shape memory, antibacterial activity, as well as biocompatibility before the wound healing capability was tested in a mouse skin suture-wound model. It was demonstrated that the optimized suture is capable of both shape memory function and antibacterial activity, and promote wound healing, suggesting that the facile scalable one-step wet-spinning strategy provides a promising tool to fabricate surgical sutures for wound healing.
- Wet-spinning,
- Shape memory,
- Antibacterial activity,
- Surgical suture,
- Wound healing
1. [1]
  F.E. Muysoms, S.A. Antoniou, K. Bury, et al., Hernia 19(2015) 1-24. doi: 10.1007/s10029-014-1342-5
2. [2]
  J. Huang, L. Chen, Z. Gu, et al., J. Biomed. Nanotechnol. 15(2019) 1357-1370. doi: 10.1166/jbn.2019.2815
3. [3]
  J. Huang, L. Chen, Q. Yuan, et al., J. Biomed. Nanotechnol. 15(2019) 1371-1383. doi: 10.1166/jbn.2019.2814
4. [4]
  K. Shao, B.Q. Han, J.N. Gao, et al., J. Biomed. Mater. Res. B:Appl. Biomater. 104(2016) 116-125. doi: 10.1002/jbm.b.33307
5. [5]
  F. Alshomer, A. Madhavan, O. Pathan, et al., Curr. Med. Chem. 24(2017) 215-223. doi: 10.2174/0929867324666161118141724
6. [6]
  A. Abiri, O. Paydar, A. Tao, et al., Surg. Endosc. 31(2017) 3258-3270. doi: 10.1007/s00464-016-5356-1
7. [7]
  D.J. Kim, W. Kim, Surg. Obes. Relat. Dis. 12(2016) 77-79.
8. [8]
  Z.Z. Sheng, X. Liu, L.L. Min, et al., Chin. Chem. Lett. 28(2017) 1131-1134. doi: 10.1016/j.cclet.2017.03.033
9. [9]
  Y. Tsukamoto, H. Oshima, T. Katsumori, et al., Gan To Kagaku Ryoho 45(2018) 474-476.
10. [10]
  K. Kapoor, A.M. Bhandare, M.M.J. Farnham, et al., Resp. Physiol. Neurbi. 226(2016) 51-62. doi: 10.1016/j.resp.2015.11.015
11. [11]
  R. Duarah, Y.P. Singh, P. Gupta, et al., Biomed. Mater. 13(2018) 045004. doi: 10.1088/1748-605X/aab93c
12. [12]
  J.M. Xia, W.J. Wang, X. Hai, et al., Chin. Chem. Lett. 30(2019) 421-424. doi: 10.1016/j.cclet.2018.07.008
13. [13]
  J. Dhom, D.A. Bloes, A. Peschel, et al., J. Orthop. Res. 35(2017) 925-933. doi: 10.1002/jor.23305
14. [14]
  S. Kathju, L. Nistico, I. Tower, et al., Surg. Infect. (Larchmt) 15(2014) 592-600. doi: 10.1089/sur.2013.016
15. [15]
  J.L. Del Pozo, Expert Rev. Anti. Ther. 16(2018) 51-65. doi: 10.1080/14787210.2018.1417036
16. [16]
  R. Roy, M. Tiwari, G. Donelli, et al., Virulence 9(2018) 522-554. doi: 10.1080/21505594.2017.1313372
17. [17]
  S. Padmakumar, J. Joseph, M.H. Neppalli, et al., ACS Appl. Mater. Int. 8(2016) 6925-6934. doi: 10.1021/acsami.6b00874
18. [18]
  T.T. Wu, M.Z. Ding, C.P. Shi, et al., Chin. Chem. Lett. 31(2020) 617-625. doi: 10.1016/j.cclet.2019.07.033
19. [19]
  K.H. Wu, B.D. Yan, S.Y. Yu, Mater. Express. 9(2019) 245-254. doi: 10.1166/mex.2019.1493
20. [20]
  L. Yang, Z.X. Wang, T. Zhao, et al., Mater. Express 8(2018) 199-210.
21. [21]
  X.Q. Yin, Y. Wen, Y.J. Li, et al., Front. Chem. 6(2018) 490. doi: 10.3389/fchem.2018.00490
22. [22]
  F. Li, Y. Liu, C.B. Qu, et al., Polymer 59(2015) 155-165. doi: 10.1016/j.polymer.2014.12.067
23. [23]
  L.W. Place, S.M. Gulcius-Lagoy, J.S. Lum, Colloids Surf. A 530(2017) 76-84. doi: 10.1016/j.colsurfa.2017.07.004
24. [24]
  O. Nomura, T. Ihara, H. Sakakibara, et al., Pediatr. Int. 61(2019) 449-452. doi: 10.1111/ped.13831
1. [1]
  Zhiqi Hu , Lingling Wu , Duo Zhang , Yixue An , Jiao Wang , Binbin Zhao , Robert Chunhua Zhao , Rong Cao , Xue Yang . Ultrathin transparent metal-organic framework-based nanocomposite membranes for antibacterial wound healing. Chinese Journal of Structural Chemistry, 2025, 44(12): 100749-100749. doi: 10.1016/j.cjsc.2025.100749
2. [2]
  Zhenyu Liu , Hizbullah Malik , Muhammad Bilal Khan Niazi , Umer Shahzad Malik , Zaib Jahan , Muhammad Salman Haider , Suhaib Umer Ilyas , Rayed S. Alshareef , Honghao Hou , Dong Yang . g-C₃N₄/ZnO nano-reinforced polysulfonate-PVA dual-network hydrogels for enhanced antibacterial ability and breathable wound healing. Chinese Chemical Letters, 2026, 37(6): 111494-. doi: 10.1016/j.cclet.2025.111494
3. [3]
  Jiaxi Wang , Zhiwei Gao , Hao Liang , Qianyue Liu , Weiqian Jin , Huyang Gao , Bailei Wang , Ruikai Zhu , Jiahao Huang , Xiaowen Li , Xingmou Wu , Weijiu Mo , Yinhan Liao , Ming Gao , Xiaojie Li , Cuiping Li . NIR stimulated epigallocatechin gallate loaded polydopamine with enhanced antibacterial and ROS scavenging abilities for improved infectious wound healing. Chinese Chemical Letters, 2025, 36(7): 110569-. doi: 10.1016/j.cclet.2024.110569
4. [4]
  Ting Xu , Kexiang Chen , Zhiyuan He , Chuanzhen Zhang , Xiaoyu Li , Ziyan Zhang , Wenbo Fan , Zhishen Ge , Chenhui Cui , Yanfeng Zhang . 4D printing of reprocessable thiocyanate covalent adaptable networks with reconfigurable shape memory ability. Chinese Chemical Letters, 2026, 37(2): 111959-. doi: 10.1016/j.cclet.2025.111959
5. [5]
  Jingwen Zhao , Jianpu Tang , Zhen Cui , Limin Liu , Dayong Yang , Chi Yao . A DNA micro-complex containing polyaptamer for exosome separation and wound healing. Chinese Chemical Letters, 2024, 35(9): 109303-. doi: 10.1016/j.cclet.2023.109303
6. [6]
  Yang Hong , Qianwei Su , Xiang Wu , Qin Zhang , Jianhua Sun , Yu Wang , Jiacan Su . Biocompatible mesoporous silica: A novel nanomaterial for skin wound healing. Chinese Chemical Letters, 2026, 37(8): 111846-. doi: 10.1016/j.cclet.2025.111846
7. [7]
  Yunfen Gao , Liying Wang , Chufan Zhou , Yi Zhao , Hai Huang , Jun Wu . Low-dimensional antimicrobial nanomaterials in anti-infection treatment and wound healing. Chinese Chemical Letters, 2025, 36(3): 110028-. doi: 10.1016/j.cclet.2024.110028
8. [8]
  Zhi-Peng Zhou , Xin Wei , Ming Yan , Zhi-Guo Wang , Rui Hong , Jia-Zhuang Xu . Multifunctional selenium nanoparticles/gelatin-based nanocomposite hydrogel adhesive for accelerated full-thickness wound healing. Chinese Chemical Letters, 2025, 36(9): 111400-. doi: 10.1016/j.cclet.2025.111400
9. [9]
  Jia Lin , Le Ding , Yingting Wu , Haoyang Li , Yi Wu , Chen Li , Quangang Zhu , Zhongjian Chen , Xiaoyan Cui , Ting Wang . Photoactivatable hydrogen sulfide donors for visualizing H₂S controlled release in accelerated chronic wound healing. Chinese Chemical Letters, 2026, 37(10): 112100-. doi: 10.1016/j.cclet.2025.112100
10. [10]
  Xingyu Chen , Sihui Zhuang , Weiyao Yan , Zhengli Zeng , Jianguo Feng , Hongen Cao , Lei Yu . Synthesis, antibacterial evaluation, and safety assessment of Se@PLA as a potent bactericide against Xanthomonas oryzae pv. oryzae. Chinese Chemical Letters, 2024, 35(10): 109635-. doi: 10.1016/j.cclet.2024.109635
11. [11]
  Shanshan Cheng , Lingjing Yu , Siqi Liu , Hongyi Gao , Changan Wang , Zeyang Song , Supakorn Boonyuen , Muye Niu , Ge Wang . Regulating electron transfer between valence-variable Fe and Cu sites in bimetallic MOFs to enhance ROS generation for day-night antibacterial efficacy. Chinese Chemical Letters, 2026, 37(6): 111553-. doi: 10.1016/j.cclet.2025.111553
12. [12]
  Yang Xu , Le Ma , Yang Wang , Chunmeng Shi . Engineering strategies of biomaterial-assisted exosomes for skin wound repair: Latest advances and challenges. Chinese Chemical Letters, 2025, 36(1): 109766-. doi: 10.1016/j.cclet.2024.109766
13. [13]
  Yanye Fan , Jingjing Chen , Bichun Chen , Jinyu Bai , Bowen Yang , Feng Liang , Lijing Fang . Design, synthesis and biological evaluation of Leu₁₀-teixobactin analogues. Chinese Chemical Letters, 2025, 36(4): 110075-. doi: 10.1016/j.cclet.2024.110075
14. [14]
  Zikang Hu , Hengjie Zhang , Zhengqiu Li , Tianbao Zhao , Zhipeng Gu , Qijuan Yuan , Baoshu Chen . Multifunctional photothermal hydrogels: Design principles, various functions, and promising biological applications. Chinese Chemical Letters, 2024, 35(10): 109527-. doi: 10.1016/j.cclet.2024.109527
15. [15]
  Yang Liu , Leilei Zhang , Kaixuan Liu , Ling-Ling Wu , Hai-Yu Hu . Penicillin G acylase-responsive near-infrared fluorescent probe: Unravelling biofilm regulation and combating bacterial infections. Chinese Chemical Letters, 2024, 35(11): 109759-. doi: 10.1016/j.cclet.2024.109759
16. [16]
  Mingxiao Liu , Wenzhuo Zheng , Jianru Yi , Jiahe Li , Jiyao Li , Yi Deng , Fusong Yuan , Kunneng Liang , Zhihe Zhao . Synergistic photocatalysis and biochemical reactivity in MXene/CuO₂ nanofibrous membrane for enhanced sterilization and tissue regeneration in chronic skin wounds. Chinese Chemical Letters, 2026, 37(9): 111985-. doi: 10.1016/j.cclet.2025.111985
17. [17]
  Yaling Wei , Jiaming He , Jinsong Ding , Caiyang Lu , Wenhu Zhou , Xinjie Deng . Zinc for skin diseases treatment: Progress and prospects in advanced delivery systems. Chinese Chemical Letters, 2026, 37(10): 112425-. doi: 10.1016/j.cclet.2026.112425
18. [18]
  Kaihang Sheng , Yanshuai Wang , Siyuan Yin , Xiuling Li , Xinya Zhang , Xiaowei Li , Dechao Niu . Gold nanorods-loaded quaternized mesoporous silica nanospheres with synergistic adhesion and photothermal antibacterial mechanism for diabetic wound healing. Chinese Chemical Letters, 2026, 37(8): 111852-. doi: 10.1016/j.cclet.2025.111852
19. [19]
  Yueying Wang , Jianming Xiong , Linwei Xin , Yuanyuan Li , He Huang , Wenjun Miao . Photosensitizer-synergized g-carbon nitride nanosheets with enhanced photocatalytic activity for eradicating drug-resistant bacteria and promoting wound healing. Chinese Chemical Letters, 2025, 36(4): 110003-. doi: 10.1016/j.cclet.2024.110003
20. [20]
  Wenlei Yang , Lingyao Wang , Yuanbin Zhang . A shape-memory hydrogen-bonded organic framework for flue gas desulfurization. Chinese Journal of Structural Chemistry, 2025, 44(6): 100574-100574. doi: 10.1016/j.cjsc.2025.100574

Get Citation

PDF

XML

Metrics

PDF Downloads(16)
Abstract views(4861)
HTML views(1262)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142