Citation: Tian Luyuan, Ma Yuxiao, Li Ming, Tang Qiaorong, Miao Luyang, Geng Bing, Li He. Biomimetic synthesis of all-inclusive organic-inorganic nanospheres for enhanced electrochemical immunoassay[J]. Chinese Chemical Letters, ;2020, 31(5): 1159-1161. doi: 10.1016/j.cclet.2019.10.007 shu

Biomimetic synthesis of all-inclusive organic-inorganic nanospheres for enhanced electrochemical immunoassay

Tian Luyuan ^a ,
Ma Yuxiao ^b ,
Li Ming ^a ,
Tang Qiaorong ^a ,
Miao Luyang ^a ,
Geng Bing ^a,**, ,
Li He ^a,c,*

a.
School of Chemistry and Chemical Engineering and Institute of Surface Analysis and Chemical Biology, University of Jinan, Ji'nan 250022, China
b.
The Hospital of University of Jinan, Ji'nan 250022, China
c.
College of Optoelectronics Technology, Chengdu University of Information Technology, Chengdu 610225, China

^**

chm_gengb@ujn.edu.cn

lihecd@gmail.com

Received Date: 25 July 2019
Revised Date: 7 October 2019
Accepted Date: 9 October 2019
Available Online: 15 October 2019

Figures(3)

A friendly biomimetic process was adopted for the mild preparation of "all-inclusive" organic-inorganic nanospheres, which effectively integrate biorecognition function and signal amplification function. The resulted Ca₃(PO₄)₂-Ab₂-BSA nanospheres were employed as signal labels for enhancing detection of nuclear matrix protein 22 (NMP 22). The fabricated electrochemical immunosensor exhibited a linear range (0.08-77.00 U/mL) and an ultralow limit of detection (0.01 U/mL) towards NMP 22, which can be taken as a promising tool for clinical diagnosis of bladder cancer.
- Nuclear matrix protein 22,
- Biomimetic process,
- Electrochemical immunosensor,
- Limit of detection
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沈阳化工大学材料科学与工程学院沈阳 110142