Citation: Gao Junbo, Zhang Xingjie, Shang Kun, Zhong Weimao, Zhang Ruihan, Dai Xiaochang, Li Xiaoli, Wang Qi, Zou Yan, Xiao Weilie. Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation[J]. Chinese Chemical Letters, ;2020, 31(2): 427-430. doi: 10.1016/j.cclet.2019.09.020 shu

Anti-NLRP3 inflammasome abietane diterpenoids from Callicarpa bodinieri and their structure elucidation

Gao Junbo ^a,b,1 ,
Zhang Xingjie ^a,1 ,
Shang Kun ^a,1 ,
Zhong Weimao ^b ,
Zhang Ruihan ^a ,
Dai Xiaochang ^a ,
Li Xiaoli ^a,* ,
Wang Qi ^a ,
Zou Yan ^a ,
Xiao Weilie ^a,*

a.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
b.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China

lixiaoli@ynu.edu.cn

xiaoweilie@ynu.edu.cn

Received Date: 7 August 2019
Revised Date: 7 September 2019
Accepted Date: 10 September 2019
Available Online: 11 September 2019

Figures(5)

Callicarpa bodinieri is a Chinese traditional medicine herbwith anti-inflammatory activity in clinic. Herein, we report two new 9, 10-seco and etherified abietane diterpenoids bodinieric acids J and K(1 and 2)and one known compound (3) isolated from the leaves and twigs of this plant. Their chemical structures were elucidated by detailed spectrometry data analysis and DP4+ NMR calculation methods. Hypothetical biosynthetic pathways of 1-3 were preliminarily speculated. Compound 3 inhibited inflammasome activation and exhibited blockage of NLRP3 inflammasome activation at non-cytotoxic concentrations in vitro.
- Callicarpa bodinieri,
- Abietane-type diterpenoids,
- DP4+ NMR calculation,
- Anti-inflammation,
- Pyroptosis,
- NLRP3 inflammasome
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