Citation: Yang Wulin, Wang Hao, Pan Zirong, Li Zhong, Deng Weiping. Asymmetric synthesis of pyrrolo[1, 2-a]indoles via organocatalytic[3 + 2] annulation of substituted 2-vinylindoles with azlactones[J]. Chinese Chemical Letters, ;2020, 31(3): 721-724. doi: 10.1016/j.cclet.2019.09.008 shu

Asymmetric synthesis of pyrrolo[1, 2-a]indoles via organocatalytic[3 + 2] annulation of substituted 2-vinylindoles with azlactones

    * Corresponding author.
    E-mail address: lizhong@ecust.edu.cn (Z. Li).
  • Received Date: 5 August 2019
    Revised Date: 29 August 2019
    Accepted Date: 29 August 2019
    Available Online: 22 March 2020

Figures(4)

  • The chiral phosphoric acid catalyzed asymmetric[3 + 2] annulation of substituted 2-vinylindoles with azlactones has been established. This reaction represented a practical approach for the synthesis of structurally diverse pyrrolo[1, 2-a]indoles with two vicinal stereocenters including one tetrasubstituted stereocenter in good yields and good stereoselectivities under mild conditions.
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