Citation: Wang Qiang, Chen Qingqing, Jiang Guoyu, Xia Mengting, Wang Mengjiao, Li Yongdong, Ma Xiaoming, Wang Jianguo, Gu Xinggui. Highly-efficient photosensitizer based on AIEgen-decorated porphyrin for protein photocleaving[J]. Chinese Chemical Letters, ;2019, 30(11): 1965-1968. doi: 10.1016/j.cclet.2019.08.037 shu

Highly-efficient photosensitizer based on AIEgen-decorated porphyrin for protein photocleaving

Wang Qiang ^a,b ,
Chen Qingqing ^a,b ,
Jiang Guoyu ^a,b,**, ,
Xia Mengting ^b ,
Wang Mengjiao ^b ,
Li Yongdong ^b ,
Ma Xiaoming ^b ,
Wang Jianguo ^a,b,**, ,
Gu Xinggui ^c,*,

a.
College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China
b.
Key Laboratory of Organo-Pharmaceutical Chemistry, Gannan Normal University, Ganzhou 341000, China
c.
Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China

^**

jiangguoyu@mail.ipc.ac.cn

wangjg@iccas.ac.cn

guxinggui@mail.buct.edu.cn

Received Date: 15 July 2019
Revised Date: 5 August 2019
Accepted Date: 22 August 2019
Available Online: 23 November 2019

Figures(5)

An AIEgen decorated porphyrin (TPETPyP) was easily obtained through a one-step reaction. The bulky TPE in TPETPyP greatly impeded the intermolecular π-π stacking of the porphyrin core, which significantly suppressed aggregation-caused quenching (ACQ) effect of TPETPyP in aqueous solution. The four pyridinium salts formed in TPETPyP also render the whole molecule water solubility, which eliminated its aggregation. TPETPyP exhibited ¹O₂ quantum yield as high as 0.85 in PBS. Moreover, it also showed high binding affinity to proteins, the major biotarget of ¹O₂. The high ¹O₂ quantum yield plus the great binding ability of TPETPyP toward proteins makes it a highly-efficient protein photocleaving agent. Protein electrophoresis experiments demonstrated that TPETPyP can photocleave BSA upon visible light irradiation, indicating that TPETPyP can act as a promising photosensitizer (PS) in PDT. The work here will provide a facile strategy to utilize AIEgens modified traditional PSs for photodynamic therapy (PDT).
- AIEgen,
- Porphyrin,
- Singlet oxygen quantum yield,
- Protein photoclevage
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