Citation: Zhang Zhijie, Wang Fang, Chen Xiaoqiang. Recent advances in the development of polydiacetylene-based biosensors[J]. Chinese Chemical Letters, ;2019, 30(10): 1745-1757. doi: 10.1016/j.cclet.2019.08.035 shu

Recent advances in the development of polydiacetylene-based biosensors

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM), Nanjing Tech University, Nanjing 210009, China

wf620@126.com

chenxq@njtech.edu.cn

chenxq@njut.edu.cn

Received Date: 25 June 2019
Revised Date: 21 August 2019
Accepted Date: 21 August 2019
Available Online: 22 October 2019

Figures(23)

Biosensors that effectively and selectively detect biomolecules and monitor biological processes have become an important component of biological and medical studies. Because they possess several attractive features, polydiacetylenes (PDAs) have been employed as frameworks for fluorometric and colorimetric sensors. PDAs are formed in their non-fluorescent blue-colored state by UV light induced polymerization of head group functionalized diacetylene monomers (DAs) and they undergo a transition to form fluorescent red-colored PDAs in response to a variety of stimuli. Importantly, by properly choosing a headgroup in the DA, the formed PDA can be designed to undergo a fluorescence/colorimetric change in response to a specific biological stimulus. This review summarizes recent advances that have been made in the development of PDA biosensors with an emphasis being given to design strategies and applications.
- Polydiacetylene,
- Biosensors,
- Fluorescent probe,
- Detection,
- Targeted
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