Citation: Fan Fangbin, Pan Jingjun, Li Yijing, Wang Licheng, Wang Shuai, Liang Xiaojing, Guo Yong. A novel double polymer modified hydrophobic/hydrophilic stationary phase for liquid chromatography[J]. Chinese Chemical Letters, ;2020, 31(3): 746-750. doi: 10.1016/j.cclet.2019.08.030 shu

A novel double polymer modified hydrophobic/hydrophilic stationary phase for liquid chromatography

Fan Fangbin ^a,b ,
Pan Jingjun ^c ,
Li Yijing ^a ,
Wang Licheng ^a ,
Wang Shuai ^a ,
Liang Xiaojing ^a,*, ,
Guo Yong ^a,*,

a.
Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Engineering Technology Institute of Xinjiang Oilfield Company, Kelamayi 834000, China

xjliang@licp.cas.cn

guoyong@licp.cas.cn

Received Date: 12 July 2019
Revised Date: 15 August 2019
Accepted Date: 20 August 2019
Available Online: 22 August 2019

Figures(7)

In this paper, norbornene imidazolium hexafluorophosphate (NM-MIm-PF₆) was modified on the surface of aminopropyl silica by ring-opening metathesis polymerization (ROMP), and then oligo(ethylene glycol) methacrylate (OEGMA) were grafted on the surface by atom transfer radical polymerization (ATRP). Some characterizations in this article confirmed that the synthesis of P(NM-MIm-PF₆)-SiPOEGMA (P1-Si-P2) is successful. The P1-Si-P2 can separate sugars, amino acids, sulfonamides in a hydrophilic interaction mode and alkyl benzene, polycyclic aromatic hydrocarbon in a reverse phase mode. The experiment also found that the column has typical characteristics of hydrophobic/hydrophilic separation mechanism. Compared to single hydrophobic C18 column and single hydrophilic Si-NH₂ column, this P1-Si-P2 shows certain advantages.
- Norbornene imidazolium,
- hexafluorophosphate (NM-MIm-PF₆),
- Oligo(ethylene glycol)methacrylate,
- (OEGMA),
- Hydrophobic,
- Hydrophilic,
- Liquid chromatography (LC)
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