Citation: Hao Yongjia, Gong Yi, Cao Zhongyan, Zhou Ying, Zhou Jian. A highly efficient In(OTf)₃-catalyzed [3 + 3] annulation of spirocyclopropyl oxindoles with 1, 4-di-thiane-2, 5-diol[J]. Chinese Chemical Letters, ;2020, 31(3): 681-684. doi: 10.1016/j.cclet.2019.08.018 shu

A highly efficient In(OTf)₃-catalyzed [3 + 3] annulation of spirocyclopropyl oxindoles with 1, 4-di-thiane-2, 5-diol

Hao Yongjia ^a ,
Gong Yi ^b ,
Cao Zhongyan ^b ,
Zhou Ying ^a,*, ,
Zhou Jian ^b,*,

a.
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China
b.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, China

yingzhou71@126.com

jzhou@chem.ecnu.edu.cn

Received Date: 29 May 2019
Revised Date: 23 July 2019
Accepted Date: 14 August 2019
Available Online: 16 August 2019

Figures(4)

Spirooxindoles play an important role in drug discovery and development. The development of efficient methods for the synthesis of spirooxindoles from easily available starting materials is of current interest. Herein, we report in detail the In(OTf)₃-catalyzed [3 + 3] annulation of spirocyclopropyl oxindoles and 1, 4-di-thiane-2, 5-diol, which allows the facile preparation of spiro[indoline-3, 4'-thiopyran]-2-ones bearing (tetrahydro)thiopyran skeleton.
- Spirooxindoles,
- Lewis acid catalysis,
- [3 + 3] cycloaddition,
- Sulfur heterocycles,
- Cyclopropane
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A highly efficient In(OTf)3-catalyzed [3 + 3] annulation of spirocyclopropyl oxindoles with 1, 4-di-thiane-2, 5-diol

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通讯作者: 陈斌, bchen63@163.com

A highly efficient In(OTf)₃-catalyzed [3 + 3] annulation of spirocyclopropyl oxindoles with 1, 4-di-thiane-2, 5-diol