Citation: Cui Yahan, Deng Rong, Li Xiangshuai, Wang Xinghuo, Jia Qiong, Bertrand Emilie, Meguellati Kamel, Yang Ying-Wei. Temperature-sensitive polypeptide brushes-coated mesoporous silica nanoparticles for dual-responsive drug release[J]. Chinese Chemical Letters, ;2019, 30(12): 2291-2294. doi: 10.1016/j.cclet.2019.08.017 shu

Temperature-sensitive polypeptide brushes-coated mesoporous silica nanoparticles for dual-responsive drug release

a.
International Joint Research Laboratory of Nano-Micro Architecture Chemistry, NMAC, College of Chemistry, Jilin University, Changchun, China
b.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, China

kamel_m@jlu.edu.cn

ywyang@jlu.edu.cn

Received Date: 18 July 2019
Revised Date: 4 August 2019
Accepted Date: 13 August 2019
Available Online: 14 December 2019

Figures(5)

A biopolymer-inorganic hybrid system (MSN@PBLGF) is designed and fabricated from mesoporous silica nanoparticles (MSNs) and folic acid (FA)-terminated temperature-sensitive synthetic polypeptide, i.e., poly(γ-benzyl-L-glutamate) (PBLG) derivative, through a thiol-disulfide exchange reaction, where MSNs with high drug loading capacity serve as drug nanocarriers and the biocompatible PBLG biopolymer brushes installed on MSN surface through disulfide bonds endow the system with tumor-specific recognition ability and GSH/temperature dual-stimuli responsiveness. Controlled drug release experiments indicate that DOX can be tightly hosted in the system with limited premature release, but efficiently released in response to an increased concentration of GSH and/or an elevated temperature. Intracellular experiments demonstrate that the DOX-loaded MSN@PBLGF nanohybrid shows outstanding cellular uptake and cell-growth inhibition effects on human lung cancer cell line A549 in comparison with healthy human cells such as hepatocyte cells LO2.
- Biopolymers,
- Dual targeting,
- Mesoporous materials,
- Multi-stimuli responsive,
- Poly(γ-benzyl-L-glutamate)
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1.
沈阳化工大学材料科学与工程学院沈阳 110142